multiomics_test
Summary
We would like to see if there’s any interesting insights we can find through multi-omics integration approach.
library(ggfortify)
library(ggplot2)
library(dplyr)
library(factoextra)
library(pvclust)
load(file = "/Users/yetingzhang/Desktop/sema4/challenge_questions_analysis/Paper-Code-01May2018/Data/Data.Rda")
#3head(featurepatients)
featurepatients## [1] "PTLG002" "PTLG003" "PTLG004" "PTLG005" "PTLG007" "PTLG008" "PTLG009"
## [8] "PTLG010" "PTLG012" "PTLG015" "PTLG016" "PTLG018" "PTLG019" "PTLG020"
## [15] "PTLG022" "PTLG024" "PTLG029" "PTLG002" "PTLG003" "PTLG004" "PTLG005"
## [22] "PTLG007" "PTLG008" "PTLG009" "PTLG010" "PTLG012" "PTLG015" "PTLG016"
## [29] "PTLG018" "PTLG019" "PTLG020" "PTLG022" "PTLG024" "PTLG029" "PTLG002"
## [36] "PTLG003" "PTLG004" "PTLG005" "PTLG007" "PTLG008" "PTLG009" "PTLG010"
## [43] "PTLG012" "PTLG015" "PTLG016" "PTLG018" "PTLG019" "PTLG020" "PTLG022"
## [50] "PTLG024" "PTLG029" "PTLG002" "PTLG003" "PTLG004" "PTLG005" "PTLG007"
## [57] "PTLG008" "PTLG009" "PTLG010" "PTLG012" "PTLG015" "PTLG016" "PTLG018"
## [64] "PTLG019" "PTLG020" "PTLG022" "PTLG024" "PTLG029"featuretimes## BL BL BL BL BL BL BL BL BL BL BL BL BL BL BL BL BL 1 1 1 1 1 1 1 1
## 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2
## 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
## 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
## 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
## 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4#featureweeks
df <- as.data.frame(InputData[[2]]) ## plasma luminex
head(df)## plasma-IL17F plasma-FASL plasma-TGFA plasma-MIP1A plasma-SDF1A
## PTLG002_BL 59.00 82.00 27.75 46.00 191.25
## PTLG003_BL 87.25 221.50 48.50 71.50 186.25
## PTLG004_BL 686.50 1088.50 453.75 252.25 575.50
## PTLG005_BL 91.25 112.75 31.00 91.00 272.00
## PTLG007_BL 186.75 544.75 194.25 171.25 345.75
## PTLG008_BL 69.50 105.75 97.50 62.00 192.00
## plasma-IL27 plasma-LIF plasma-IL1B plasma-IL2 plasma-IL4
## PTLG002_BL 70.5 35.50 28.00 31.00 56.50
## PTLG003_BL 192.5 31.00 22.00 23.50 125.50
## PTLG004_BL 1028.5 232.00 58.25 147.50 605.00
## PTLG005_BL 104.5 34.50 32.00 32.75 67.50
## PTLG007_BL 389.5 40.75 36.50 51.00 276.75
## PTLG008_BL 78.5 33.50 31.00 41.75 63.50
## plasma-IL5 plasma-IP10 plasma-IL6 plasma-IL7 plasma-IL8
## PTLG002_BL 37.50 106.50 53.00 40.50 79.00
## PTLG003_BL 22.00 260.00 183.25 55.50 189.50
## PTLG004_BL 298.75 781.50 931.50 289.25 912.50
## PTLG005_BL 40.75 204.25 92.50 38.75 110.75
## PTLG007_BL 47.50 556.25 521.50 51.00 480.00
## PTLG008_BL 45.50 218.50 74.50 70.00 109.50
## plasma-IL10 plasma-IFNB plasma-EOTAXIN plasma-IL12P70
## PTLG002_BL 112.00 169.00 37.5 49.5
## PTLG003_BL 160.00 67.00 53.5 78.5
## PTLG004_BL 768.75 697.00 82.0 1026.5
## PTLG005_BL 104.50 51.25 38.5 67.0
## PTLG007_BL 351.00 52.00 34.0 187.0
## PTLG008_BL 115.00 37.50 71.0 46.0
## plasma-IL13 plasma-IL17A plasma-IL31 plasma-IL1RA plasma-SCF
## PTLG002_BL 60.00 47.50 30.50 29.50 58.50
## PTLG003_BL 151.25 48.25 51.00 24.50 79.00
## PTLG004_BL 877.00 547.50 101.00 52.00 490.00
## PTLG005_BL 94.25 49.75 30.50 31.25 59.25
## PTLG007_BL 387.00 84.50 90.75 29.50 125.75
## PTLG008_BL 63.00 106.75 39.75 31.50 57.50
## plasma-RANTES plasma-IFNG plasma-GMCSF plasma-TNFA plasma-HGF
## PTLG002_BL 5120.00 50.50 31.00 156.50 49.5
## PTLG003_BL 4429.00 108.00 220.00 169.50 31.0
## PTLG004_BL 4850.00 449.50 392.00 243.00 104.0
## PTLG005_BL 2945.25 54.00 100.50 160.50 62.5
## PTLG007_BL 1833.50 219.25 214.25 184.00 37.5
## PTLG008_BL 3795.75 52.25 42.50 128.75 36.5
## plasma-MIP1B plasma-IFNA plasma-TGFB plasma-MCP1 plasma-IL9
## PTLG002_BL 216.00 112.5 45.0 73.2775 52.50
## PTLG003_BL 235.25 188.5 49.0 104.0550 115.00
## PTLG004_BL 576.25 422.5 274.5 215.8500 781.00
## PTLG005_BL 187.75 102.0 48.5 81.7500 71.25
## PTLG007_BL 345.00 138.5 48.5 165.7825 380.25
## PTLG008_BL 297.50 87.0 52.5 57.5000 58.50
## plasma-VEGFD plasma-TNFB plasma-NGF plasma-EGF plasma-BDNF
## PTLG002_BL 218.0 56.50 37.50 45.00 905.0
## PTLG003_BL 83.0 132.75 71.25 146.25 226.0
## PTLG004_BL 161.0 874.00 272.00 519.25 1009.5
## PTLG005_BL 147.5 70.25 42.50 63.50 230.0
## PTLG007_BL 76.0 365.00 138.25 145.25 447.5
## PTLG008_BL 114.5 67.00 44.00 60.50 3547.0
## plasma-TRAIL plasma-GCSF plasma-GROA plasma-IL1A plasma-IL23
## PTLG002_BL 74.50 41.00 33.50 163.50 67.00
## PTLG003_BL 93.50 43.50 85.50 237.50 201.25
## PTLG004_BL 379.75 169.00 301.50 830.00 1072.50
## PTLG005_BL 105.00 47.25 49.50 187.25 121.75
## PTLG007_BL 221.50 82.75 180.00 449.75 591.25
## PTLG008_BL 92.25 45.00 55.25 195.00 86.75
## plasma-IL12P40 plasma-IL15 plasma-IL18 plasma-MCSF plasma-MCP3
## PTLG002_BL 301.50 49.5 458.00 82.00 40.00
## PTLG003_BL 317.50 54.0 457.00 211.00 38.50
## PTLG004_BL 587.75 270.5 1497.50 952.75 276.00
## PTLG005_BL 216.00 45.0 368.25 125.50 48.75
## PTLG007_BL 207.25 43.5 767.25 496.50 73.00
## PTLG008_BL 246.75 46.5 404.50 83.50 41.00
## plasma-MIG plasma-RESISTIN plasma-IL21 plasma-ICAM1
## PTLG002_BL 55.00 6791.50 35.5 1578.50
## PTLG003_BL 51.50 6377.50 34.0 1754.75
## PTLG004_BL 180.50 6057.00 126.0 2055.00
## PTLG005_BL 64.00 5574.50 48.0 812.50
## PTLG007_BL 90.00 4879.25 52.0 1764.50
## PTLG008_BL 56.75 4848.75 46.0 1650.50
## plasma-VCAM1 plasma-FGFB plasma-IL22 plasma-PDGFBB plasma-VEGF
## PTLG002_BL 15781.00 50.50 43.0000 62.50 164.00
## PTLG003_BL 16228.25 90.00 79.6375 267.75 226.00
## PTLG004_BL 15889.00 565.50 144.7500 1145.50 845.00
## PTLG005_BL 14052.75 162.25 38.0000 256.00 222.75
## PTLG007_BL 16098.00 353.75 53.2500 1388.25 469.00
## PTLG008_BL 13638.50 59.00 52.5000 143.00 233.50
## plasma-LEPTIN plasma-PAI1 plasma-CD40L plasma-ENA78
## PTLG002_BL 1533.5 3707.50 115.75 213.50
## PTLG003_BL 8900.5 2319.00 141.50 158.50
## PTLG004_BL 2001.5 3481.25 2731.75 724.25
## PTLG005_BL 6240.0 1768.50 120.75 178.50
## PTLG007_BL 9325.0 1855.50 176.00 301.25
## PTLG008_BL 627.0 3205.00 80.00 665.25###quick EDA
pca_1st <- prcomp(df[18:33,])
#first_tri <- (row.names(df[17:33,]))
fviz_eig(pca_1st)
# the scree plot shows that the top 2 pcas already explained the majority of the variances in the data
# plot pc1 vs pc2 using postpartum patients microbiome dataset
fviz_pca_ind(pca_1st,
col.ind = "cos2", # Color by the quality of representation
gradient.cols = c("#00AFBB", "#E7B800", "#FC4E07"),
repel = TRUE # Avoid text overlapping
)
## Take a look into first trimestor, as that's one of the important stage.
dis <- scale(df[18:33,], center = TRUE)
#dist_mat <- dist(dis, method = 'euclidean')
#hclust_avg <- hclust(dist_mat, method = 'average')
#plot(hclust_avg)
##use pvclust to get a confidence values
pv <- pvclust(t(dis), nboot=1000)## Bootstrap (r = 0.5)... Done.
## Bootstrap (r = 0.6)... Done.
## Bootstrap (r = 0.69)... Done.
## Bootstrap (r = 0.79)... Done.
## Bootstrap (r = 0.89)... Done.
## Bootstrap (r = 1.0)... Done.
## Bootstrap (r = 1.1)... Done.
## Bootstrap (r = 1.19)... Done.
## Bootstrap (r = 1.29)... Done.
## Bootstrap (r = 1.39)... Done.plot(pv, cex=0.8, cex.pv=0.7)
##G010_1, G003_1,G024_1, G002_1, G005_1 as one cluster and rest as the second cluster
df2 <- df[18:33,]
rownames(df2)## [1] "PTLG002_1" "PTLG003_1" "PTLG004_1" "PTLG005_1" "PTLG007_1"
## [6] "PTLG008_1" "PTLG009_1" "PTLG010_1" "PTLG012_1" "PTLG015_1"
## [11] "PTLG016_1" "PTLG018_1" "PTLG019_1" "PTLG020_1" "PTLG022_1"
## [16] "PTLG024_1"df2$clus <- c(1,1,0,1,0,0,0,1,0,0,0,0,0,0,0,1)Look into the patients divided into subgroups
## we can also visualize the plasma readings for each
for (i in 1: (ncol(df2)-1)){
hist(df2[,i], breaks = 10, main = names(df2)[i])
}
## take a look at correlation
library(corrplot)
correlations <- cor(df2)
corrplot(correlations, method="circle")
## build a logistic regression model using df2 dataframe
for (i in 1:(ncol(df2)-1)){
test <- cor.test(df2[,i], df2$clus)
if (test$p.value <=0.05){
print(colnames(df2)[i])
print(test)
}
}## [1] "plasma-TGFA"
##
## Pearson's product-moment correlation
##
## data: df2[, i] and df2$clus
## t = -2.5024, df = 14, p-value = 0.02535
## alternative hypothesis: true correlation is not equal to 0
## 95 percent confidence interval:
## -0.8244342 -0.0831210
## sample estimates:
## cor
## -0.5559205
##
## [1] "plasma-MIP1B"
##
## Pearson's product-moment correlation
##
## data: df2[, i] and df2$clus
## t = -2.5008, df = 14, p-value = 0.02543
## alternative hypothesis: true correlation is not equal to 0
## 95 percent confidence interval:
## -0.82432384 -0.08277893
## sample estimates:
## cor
## -0.5556824
##
## [1] "plasma-MCP1"
##
## Pearson's product-moment correlation
##
## data: df2[, i] and df2$clus
## t = -2.4362, df = 14, p-value = 0.0288
## alternative hypothesis: true correlation is not equal to 0
## 95 percent confidence interval:
## -0.81965029 -0.06845128
## sample estimates:
## cor
## -0.5456421
##
## [1] "plasma-BDNF"
##
## Pearson's product-moment correlation
##
## data: df2[, i] and df2$clus
## t = -4.5001, df = 14, p-value = 0.0004991
## alternative hypothesis: true correlation is not equal to 0
## 95 percent confidence interval:
## -0.9156315 -0.4415154
## sample estimates:
## cor
## -0.7689313
##
## [1] "plasma-VCAM1"
##
## Pearson's product-moment correlation
##
## data: df2[, i] and df2$clus
## t = 3.0593, df = 14, p-value = 0.008492
## alternative hypothesis: true correlation is not equal to 0
## 95 percent confidence interval:
## 0.2000388 0.8591175
## sample estimates:
## cor
## 0.6329779## BDNF and VCAM1 strongest signal
##head(df2)
glm.fit <- glm(clus ~ df2$`plasma-TGFA` + df2$`plasma-VCAM1` + df2$`plasma-BDNF` + df2$`plasma-MCP1` + df2$`plasma-MIP1B` , data = df2, family = binomial)
summary(glm.fit)##
## Call:
## glm(formula = clus ~ df2$`plasma-TGFA` + df2$`plasma-VCAM1` +
## df2$`plasma-BDNF` + df2$`plasma-MCP1` + df2$`plasma-MIP1B`,
## family = binomial, data = df2)
##
## Deviance Residuals:
## Min 1Q Median 3Q Max
## -1.499e-05 -2.110e-08 -2.110e-08 2.110e-08 1.091e-05
##
## Coefficients:
## Estimate Std. Error z value Pr(>|z|)
## (Intercept) -4.096e+01 2.041e+06 0 1
## df2$`plasma-TGFA` 1.420e-01 1.841e+03 0 1
## df2$`plasma-VCAM1` 1.657e-02 1.273e+02 0 1
## df2$`plasma-BDNF` -8.427e-03 1.463e+02 0 1
## df2$`plasma-MCP1` -1.441e+00 3.693e+03 0 1
## df2$`plasma-MIP1B` -3.729e-01 3.407e+03 0 1
##
## (Dispersion parameter for binomial family taken to be 1)
##
## Null deviance: 1.9875e+01 on 15 degrees of freedom
## Residual deviance: 5.9300e-10 on 10 degrees of freedom
## AIC: 12
##
## Number of Fisher Scoring iterations: 25glm.fit <- glm(clus ~ df2$`plasma-TGFA` , data = df2, family = binomial)
summary(glm.fit)##
## Call:
## glm(formula = clus ~ df2$`plasma-TGFA`, family = binomial, data = df2)
##
## Deviance Residuals:
## Min 1Q Median 3Q Max
## -1.13661 -0.51835 -0.06272 0.14251 1.67511
##
## Coefficients:
## Estimate Std. Error z value Pr(>|z|)
## (Intercept) 6.69565 5.16715 1.296 0.195
## df2$`plasma-TGFA` -0.08360 0.05629 -1.485 0.138
##
## (Dispersion parameter for binomial family taken to be 1)
##
## Null deviance: 19.8748 on 15 degrees of freedom
## Residual deviance: 9.3253 on 14 degrees of freedom
## AIC: 13.325
##
## Number of Fisher Scoring iterations: 8glm.fit <- glm(clus ~ df2$`plasma-VCAM1` , data = df2, family = binomial)
summary(glm.fit)##
## Call:
## glm(formula = clus ~ df2$`plasma-VCAM1`, family = binomial, data = df2)
##
## Deviance Residuals:
## Min 1Q Median 3Q Max
## -1.6125 -0.5526 -0.2681 0.2251 1.7300
##
## Coefficients:
## Estimate Std. Error z value Pr(>|z|)
## (Intercept) -49.085660 26.979205 -1.819 0.0689 .
## df2$`plasma-VCAM1` 0.003295 0.001834 1.797 0.0724 .
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## (Dispersion parameter for binomial family taken to be 1)
##
## Null deviance: 19.875 on 15 degrees of freedom
## Residual deviance: 11.495 on 14 degrees of freedom
## AIC: 15.495
##
## Number of Fisher Scoring iterations: 6glm.fit <- glm(clus ~ df2$`plasma-BDNF` , data = df2, family = binomial)
summary(glm.fit)##
## Call:
## glm(formula = clus ~ df2$`plasma-BDNF`, family = binomial, data = df2)
##
## Deviance Residuals:
## Min 1Q Median 3Q Max
## -1.1587 -0.2301 -0.0766 0.1105 1.8877
##
## Coefficients:
## Estimate Std. Error z value Pr(>|z|)
## (Intercept) 5.607621 3.617047 1.55 0.1211
## df2$`plasma-BDNF` -0.002767 0.001618 -1.71 0.0872 .
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## (Dispersion parameter for binomial family taken to be 1)
##
## Null deviance: 19.875 on 15 degrees of freedom
## Residual deviance: 7.395 on 14 degrees of freedom
## AIC: 11.395
##
## Number of Fisher Scoring iterations: 7glm.fit <- glm(clus ~ df2$`plasma-MCP1` , data = df2, family = binomial)
summary(glm.fit)##
## Call:
## glm(formula = clus ~ df2$`plasma-MCP1`, family = binomial, data = df2)
##
## Deviance Residuals:
## Min 1Q Median 3Q Max
## -1.36285 -0.38531 -0.06863 0.23370 1.96133
##
## Coefficients:
## Estimate Std. Error z value Pr(>|z|)
## (Intercept) 10.88083 6.25690 1.739 0.082 .
## df2$`plasma-MCP1` -0.16023 0.08875 -1.805 0.071 .
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## (Dispersion parameter for binomial family taken to be 1)
##
## Null deviance: 19.8748 on 15 degrees of freedom
## Residual deviance: 8.8399 on 14 degrees of freedom
## AIC: 12.84
##
## Number of Fisher Scoring iterations: 7glm.fit <- glm(clus ~ df2$`plasma-MIP1B` , data = df2, family = binomial)
summary(glm.fit)##
## Call:
## glm(formula = clus ~ df2$`plasma-MIP1B`, family = binomial, data = df2)
##
## Deviance Residuals:
## Min 1Q Median 3Q Max
## -1.39305 -0.44478 -0.09012 0.21567 1.64267
##
## Coefficients:
## Estimate Std. Error z value Pr(>|z|)
## (Intercept) 15.69142 9.75739 1.608 0.1078
## df2$`plasma-MIP1B` -0.06565 0.03978 -1.650 0.0989 .
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## (Dispersion parameter for binomial family taken to be 1)
##
## Null deviance: 19.875 on 15 degrees of freedom
## Residual deviance: 10.359 on 14 degrees of freedom
## AIC: 14.359
##
## Number of Fisher Scoring iterations: 7##BDNF strongest p-values associated with the subgroupUse mixOmics to dig in more interesting insights
library(mixOmics)
## look into immune system
df_im <- as.data.frame(InputData[[5]]) ## immune_system
head(df_im)## Bcells CD16+CD56-NKcells CD4+Tcells_mem CD4+Tcells_naive
## PTLG002_BL 0.05316363 0.054978381 0.2978747 0.13628890
## PTLG003_BL 0.13733348 0.061311029 0.2742815 0.13959263
## PTLG004_BL 0.10306745 0.004127739 0.1627464 0.10394971
## PTLG005_BL 0.14980225 0.058160536 0.1418806 0.25710432
## PTLG007_BL 0.12417738 0.037422496 0.2352829 0.13274168
## PTLG008_BL 0.09616602 0.127325297 0.1960597 0.07126728
## CD4+Tcells CD45RA+Tregs CD45RA-Tregs CD56+CD16-NKcells
## PTLG002_BL 0.4458316 0.002569880 0.013848121 0.007051946
## PTLG003_BL 0.4222384 0.004930701 0.013510121 0.004392807
## PTLG004_BL 0.2708396 0.003198210 0.007987648 0.007152648
## PTLG005_BL 0.4067580 0.013168423 0.009567682 0.002663405
## PTLG007_BL 0.3745355 0.003886490 0.008934921 0.001813028
## PTLG008_BL 0.2750212 0.002927156 0.015137576 0.007276073
## CD7+NKcells CD8+Tcells_mem CD8+Tcells_naive CD8+Tcells
## PTLG002_BL 0.07083612 0.11888435 0.08696182 0.2085622
## PTLG003_BL 0.07506320 0.06936152 0.12489018 0.1964302
## PTLG004_BL 0.09076300 0.05706363 0.06399571 0.1216423
## PTLG005_BL 0.06900848 0.06327016 0.08158250 0.1467616
## PTLG007_BL 0.04458446 0.15057145 0.14185690 0.2980978
## PTLG008_BL 0.14730164 0.10084947 0.05528143 0.1579947
## cMCs Gr intMCs M-MDSC mDCs
## PTLG002_BL 0.12144206 0.7494255 0.006516047 0.004676938 0.017818647
## PTLG003_BL 0.10338336 0.5723880 0.008946982 0.002841877 0.012048841
## PTLG004_BL 0.31700093 0.7646071 0.000441132 0.005734722 0.032438990
## PTLG005_BL 0.12141926 0.6876881 0.003657895 0.040728378 0.010425002
## PTLG007_BL 0.05992007 0.4525439 0.002884818 0.009435758 0.005849769
## PTLG008_BL 0.22039690 0.7479697 0.006726484 0.037957443 0.014504355
## ncMCs pDCs Tbet+CD4+Tcells_mem
## PTLG002_BL 0.026892394 0.003057061 0.05507582
## PTLG003_BL 0.006535420 0.002823947 0.05721406
## PTLG004_BL 0.000393868 0.003371512 0.04991099
## PTLG005_BL 0.011568094 0.004583800 0.01390000
## PTLG007_BL 0.003966624 0.001322208 0.04636743
## PTLG008_BL 0.017586829 0.003010789 0.03736006
## Tbet+CD4+Tcells_naive Tbet+CD8+Tcells_mem Tbet+CD8+Tcells_naive
## PTLG002_BL 0.002082699 0.06822971 0.02619816
## PTLG003_BL 0.002752228 0.03963387 0.04932494
## PTLG004_BL 0.000850755 0.03429805 0.00436406
## PTLG005_BL 0.001337418 0.03651037 0.01527171
## PTLG007_BL 0.001171957 0.08043433 0.10015726
## PTLG008_BL 0.001433709 0.06244997 0.02283181
## TCRgd+Tcells Tregs Bcells_STAT1_IFNa100
## PTLG002_BL 0.008099385 0.015114792 1.883934
## PTLG003_BL 0.010417227 0.015554121 1.590320
## PTLG004_BL 0.019535866 0.009090479 1.833032
## PTLG005_BL 0.028863080 0.014197206 1.335537
## PTLG007_BL 0.009505875 0.010217062 1.097242
## PTLG008_BL 0.007192440 0.016654918 1.438130
## CD16+CD56-NKcells_STAT1_IFNa100 CD4+Tcells_mem_STAT1_IFNa100
## PTLG002_BL 1.3430740 2.681511
## PTLG003_BL 1.4153010 2.603414
## PTLG004_BL 1.5208184 2.662798
## PTLG005_BL 1.1906837 2.240182
## PTLG007_BL 0.8452553 1.964598
## PTLG008_BL 1.0641769 2.336210
## CD4+Tcells_naive_STAT1_IFNa100 CD4+Tcells_STAT1_IFNa100
## PTLG002_BL 2.572645 2.645608
## PTLG003_BL 2.559658 2.587365
## PTLG004_BL 2.562652 2.625827
## PTLG005_BL 2.056807 2.119978
## PTLG007_BL 1.741210 1.884081
## PTLG008_BL 2.378891 2.347843
## CD45RA+Tregs_STAT1_IFNa100 CD45RA-Tregs_STAT1_IFNa100
## PTLG002_BL 2.115613 2.576695
## PTLG003_BL 2.099454 2.441766
## PTLG004_BL 1.949414 2.603367
## PTLG005_BL 1.626340 2.236646
## PTLG007_BL 1.258130 1.880639
## PTLG008_BL 1.974352 2.130562
## CD56+CD16-NKcells_STAT1_IFNa100 CD7+NKcells_STAT1_IFNa100
## PTLG002_BL 2.173771 1.4954026
## PTLG003_BL 1.791405 1.4640982
## PTLG004_BL 2.007778 1.3896547
## PTLG005_BL 1.685331 1.2376270
## PTLG007_BL 1.565739 0.9041039
## PTLG008_BL 1.590980 1.0974338
## CD8+Tcells_mem_STAT1_IFNa100 CD8+Tcells_naive_STAT1_IFNa100
## PTLG002_BL 2.097842 2.391814
## PTLG003_BL 2.030723 2.233538
## PTLG004_BL 2.178770 2.822410
## PTLG005_BL 1.616216 2.068139
## PTLG007_BL 1.215192 1.140393
## PTLG008_BL 1.805588 2.027814
## CD8+Tcells_STAT1_IFNa100 cMCs_STAT1_IFNa100 Gr_STAT1_IFNa100
## PTLG002_BL 2.216081 2.818281 0.9364900
## PTLG003_BL 2.155939 3.098547 1.2513265
## PTLG004_BL 2.513076 3.291161 0.9874188
## PTLG005_BL 1.867359 2.552215 0.6618747
## PTLG007_BL 1.174225 2.392938 0.7099698
## PTLG008_BL 1.881715 2.490248 0.7945207
## intMCs_STAT1_IFNa100 M-MDSC_STAT1_IFNa100 mDCs_STAT1_IFNa100
## PTLG002_BL 3.141909 2.559876 2.787273
## PTLG003_BL 3.239390 2.859485 2.950333
## PTLG004_BL 3.146067 3.209668 3.246538
## PTLG005_BL 2.905786 2.422720 2.450239
## PTLG007_BL 2.680093 2.303223 2.293737
## PTLG008_BL 2.541689 2.363978 2.455450
## ncMCs_STAT1_IFNa100 pDCs_STAT1_IFNa100
## PTLG002_BL 2.529751 2.881487
## PTLG003_BL 2.558536 2.937936
## PTLG004_BL 1.549579 3.095097
## PTLG005_BL 2.442068 2.529682
## PTLG007_BL 1.760488 2.485999
## PTLG008_BL 2.160693 2.531458
## Tbet+CD4+Tcells_mem_STAT1_IFNa100
## PTLG002_BL 2.550036
## PTLG003_BL 2.615164
## PTLG004_BL 2.552131
## PTLG005_BL 2.357239
## PTLG007_BL 1.967606
## PTLG008_BL 2.355129
## Tbet+CD4+Tcells_naive_STAT1_IFNa100
## PTLG002_BL 2.169962
## PTLG003_BL 2.332043
## PTLG004_BL 2.707111
## PTLG005_BL 2.264583
## PTLG007_BL 1.770758
## PTLG008_BL 2.280269
## Tbet+CD8+Tcells_mem_STAT1_IFNa100
## PTLG002_BL 1.9350000
## PTLG003_BL 1.9218930
## PTLG004_BL 2.0698142
## PTLG005_BL 1.5793980
## PTLG007_BL 0.9484248
## PTLG008_BL 1.7377333
## Tbet+CD8+Tcells_naive_STAT1_IFNa100 TCRgd+Tcells_STAT1_IFNa100
## PTLG002_BL 1.3919353 2.0041135
## PTLG003_BL 1.4807853 2.0609923
## PTLG004_BL 1.9059106 2.0516879
## PTLG005_BL 1.4719667 1.5304276
## PTLG007_BL 0.7004725 0.9743522
## PTLG008_BL 1.1052087 1.6258778
## Tregs_STAT1_IFNa100 Bcells_STAT3_IFNa100
## PTLG002_BL 2.540940 1.689828
## PTLG003_BL 2.401746 1.489384
## PTLG004_BL 2.556323 1.335289
## PTLG005_BL 2.055960 1.404200
## PTLG007_BL 1.822197 1.128299
## PTLG008_BL 2.122167 1.322829
## CD16+CD56-NKcells_STAT3_IFNa100 CD4+Tcells_mem_STAT3_IFNa100
## PTLG002_BL 1.4367871 1.962873
## PTLG003_BL 1.2032096 1.771971
## PTLG004_BL 1.0767724 1.615677
## PTLG005_BL 1.2147350 1.740035
## PTLG007_BL 0.8246158 1.436556
## PTLG008_BL 1.0578945 1.474995
## CD4+Tcells_naive_STAT3_IFNa100 CD4+Tcells_STAT3_IFNa100
## PTLG002_BL 1.880874 1.936483
## PTLG003_BL 1.689527 1.743107
## PTLG004_BL 1.497626 1.569454
## PTLG005_BL 1.662133 1.689146
## PTLG007_BL 1.271081 1.375959
## PTLG008_BL 1.314365 1.428821
## CD45RA+Tregs_STAT3_IFNa100 CD45RA-Tregs_STAT3_IFNa100
## PTLG002_BL 1.778626 1.743283
## PTLG003_BL 1.565153 1.586355
## PTLG004_BL 1.276377 1.451046
## PTLG005_BL 1.529707 1.581673
## PTLG007_BL 1.109900 1.181956
## PTLG008_BL 1.280025 1.314365
## CD56+CD16-NKcells_STAT3_IFNa100 CD7+NKcells_STAT3_IFNa100
## PTLG002_BL 1.850616 1.5133375
## PTLG003_BL 1.543818 1.2394256
## PTLG004_BL 1.354657 1.0545617
## PTLG005_BL 1.634644 1.2450130
## PTLG007_BL 1.208692 0.8513588
## PTLG008_BL 1.425817 1.0780556
## CD8+Tcells_mem_STAT3_IFNa100 CD8+Tcells_naive_STAT3_IFNa100
## PTLG002_BL 1.716197 1.7909980
## PTLG003_BL 1.501789 1.5959655
## PTLG004_BL 1.371408 1.6314999
## PTLG005_BL 1.493756 1.6771131
## PTLG007_BL 1.082660 0.9755629
## PTLG008_BL 1.429668 1.3533569
## CD8+Tcells_STAT3_IFNa100 cMCs_STAT3_IFNa100 Gr_STAT3_IFNa100
## PTLG002_BL 1.745877 2.666147 1.811982
## PTLG003_BL 1.559795 2.628044 1.866700
## PTLG004_BL 1.507114 2.357877 1.252278
## PTLG005_BL 1.595699 2.381356 1.480383
## PTLG007_BL 1.028330 2.190686 1.271405
## PTLG008_BL 1.400253 2.247682 1.351230
## intMCs_STAT3_IFNa100 M-MDSC_STAT3_IFNa100 mDCs_STAT3_IFNa100
## PTLG002_BL 2.593384 2.653928 2.465627
## PTLG003_BL 2.500321 2.581935 2.341755
## PTLG004_BL 2.294054 2.269291 2.244720
## PTLG005_BL 2.381874 2.341738 2.160296
## PTLG007_BL 1.935910 2.172894 1.853800
## PTLG008_BL 2.026257 2.209571 2.085495
## ncMCs_STAT3_IFNa100 pDCs_STAT3_IFNa100
## PTLG002_BL 2.202280 2.499031
## PTLG003_BL 2.108430 2.352964
## PTLG004_BL 1.417646 2.213222
## PTLG005_BL 1.999970 2.253997
## PTLG007_BL 1.415520 2.041499
## PTLG008_BL 1.732166 2.136429
## Tbet+CD4+Tcells_mem_STAT3_IFNa100
## PTLG002_BL 1.882823
## PTLG003_BL 1.797875
## PTLG004_BL 1.574886
## PTLG005_BL 1.771802
## PTLG007_BL 1.397375
## PTLG008_BL 1.551601
## Tbet+CD4+Tcells_naive_STAT3_IFNa100
## PTLG002_BL 1.893097
## PTLG003_BL 1.748629
## PTLG004_BL 1.810199
## PTLG005_BL 1.886539
## PTLG007_BL 1.443610
## PTLG008_BL 1.558486
## Tbet+CD8+Tcells_mem_STAT3_IFNa100
## PTLG002_BL 1.6250345
## PTLG003_BL 1.4557977
## PTLG004_BL 1.3175046
## PTLG005_BL 1.5068274
## PTLG007_BL 0.9126096
## PTLG008_BL 1.4304699
## Tbet+CD8+Tcells_naive_STAT3_IFNa100 TCRgd+Tcells_STAT3_IFNa100
## PTLG002_BL 1.4633641 1.6409670
## PTLG003_BL 1.3434141 1.5735994
## PTLG004_BL 1.3428085 1.3637615
## PTLG005_BL 1.4265563 1.5488330
## PTLG007_BL 0.7653214 0.9985255
## PTLG008_BL 1.0169735 1.4093478
## Tregs_STAT3_IFNa100 Bcells_STAT5_IFNa100
## PTLG002_BL 1.739995 1.0865749
## PTLG003_BL 1.586866 1.0594177
## PTLG004_BL 1.454591 0.9069739
## PTLG005_BL 1.569893 0.9349606
## PTLG007_BL 1.187713 0.8141995
## PTLG008_BL 1.313346 0.9395698
## CD16+CD56-NKcells_STAT5_IFNa100 CD4+Tcells_mem_STAT5_IFNa100
## PTLG002_BL 0.3908686 2.020197
## PTLG003_BL 0.3030877 1.826494
## PTLG004_BL 0.3017567 1.624617
## PTLG005_BL 0.3224890 1.902369
## PTLG007_BL 0.2363487 1.717701
## PTLG008_BL 0.2747976 1.790276
## CD4+Tcells_naive_STAT5_IFNa100 CD4+Tcells_STAT5_IFNa100
## PTLG002_BL 1.772633 1.940625
## PTLG003_BL 1.627500 1.759162
## PTLG004_BL 1.420053 1.549337
## PTLG005_BL 1.556633 1.679582
## PTLG007_BL 1.426656 1.613615
## PTLG008_BL 1.533184 1.715367
## CD45RA+Tregs_STAT5_IFNa100 CD45RA-Tregs_STAT5_IFNa100
## PTLG002_BL 1.753596 2.019936
## PTLG003_BL 1.594411 1.864885
## PTLG004_BL 1.265761 1.794600
## PTLG005_BL 1.510541 1.910700
## PTLG007_BL 1.307160 1.771011
## PTLG008_BL 1.429167 1.752876
## CD56+CD16-NKcells_STAT5_IFNa100 CD7+NKcells_STAT5_IFNa100
## PTLG002_BL 1.0140372 0.5319485
## PTLG003_BL 0.8239295 0.3731726
## PTLG004_BL 0.6455759 0.3400892
## PTLG005_BL 0.8706003 0.3808675
## PTLG007_BL 0.7085075 0.3069732
## PTLG008_BL 0.7293671 0.3210165
## CD8+Tcells_mem_STAT5_IFNa100 CD8+Tcells_naive_STAT5_IFNa100
## PTLG002_BL 1.3051328 1.4477503
## PTLG003_BL 1.1728075 1.1836675
## PTLG004_BL 1.0435859 1.3294225
## PTLG005_BL 1.1517025 1.3528572
## PTLG007_BL 0.9033031 0.6961842
## PTLG008_BL 1.2135812 1.1629976
## CD8+Tcells_STAT5_IFNa100 cMCs_STAT5_IFNa100 Gr_STAT5_IFNa100
## PTLG002_BL 1.3605056 1.902063 1.0942275
## PTLG003_BL 1.1763311 2.013573 1.1997768
## PTLG004_BL 1.1905903 1.903802 0.9641738
## PTLG005_BL 1.2625255 1.628654 0.8099483
## PTLG007_BL 0.7976803 1.887401 1.0349917
## PTLG008_BL 1.1921450 1.830637 1.2142773
## intMCs_STAT5_IFNa100 M-MDSC_STAT5_IFNa100 mDCs_STAT5_IFNa100
## PTLG002_BL 1.615392 1.893506 1.961580
## PTLG003_BL 1.667373 1.991591 2.032876
## PTLG004_BL 1.521164 1.870059 1.866350
## PTLG005_BL 1.479818 1.575791 1.784715
## PTLG007_BL 1.609355 1.858535 1.936220
## PTLG008_BL 1.532984 1.810649 1.881227
## ncMCs_STAT5_IFNa100 pDCs_STAT5_IFNa100
## PTLG002_BL 1.3353245 1.495443
## PTLG003_BL 1.3617494 1.595920
## PTLG004_BL 0.7115761 1.588542
## PTLG005_BL 1.3103494 1.402652
## PTLG007_BL 1.0785812 1.419174
## PTLG008_BL 1.3443303 1.437497
## Tbet+CD4+Tcells_mem_STAT5_IFNa100
## PTLG002_BL 1.689822
## PTLG003_BL 1.587442
## PTLG004_BL 1.264565
## PTLG005_BL 1.742680
## PTLG007_BL 1.437438
## PTLG008_BL 1.681099
## Tbet+CD4+Tcells_naive_STAT5_IFNa100
## PTLG002_BL 1.467632
## PTLG003_BL 1.330122
## PTLG004_BL 1.445521
## PTLG005_BL 1.479403
## PTLG007_BL 1.395989
## PTLG008_BL 1.358936
## Tbet+CD8+Tcells_mem_STAT5_IFNa100
## PTLG002_BL 1.1080226
## PTLG003_BL 0.9843562
## PTLG004_BL 0.8832410
## PTLG005_BL 1.0936206
## PTLG007_BL 0.5654855
## PTLG008_BL 1.1104924
## Tbet+CD8+Tcells_naive_STAT5_IFNa100 TCRgd+Tcells_STAT5_IFNa100
## PTLG002_BL 0.6882918 1.2220701
## PTLG003_BL 0.5877077 1.1143876
## PTLG004_BL 0.8312933 0.8617033
## PTLG005_BL 0.9551179 1.0075779
## PTLG007_BL 0.3231430 0.5597269
## PTLG008_BL 0.5339332 1.0166648
## Tregs_STAT5_IFNa100 Bcells_ERK_IL100
## PTLG002_BL 2.001394 0.11118083
## PTLG003_BL 1.835849 0.03854602
## PTLG004_BL 1.740703 0.07256374
## PTLG005_BL 1.797600 0.02382912
## PTLG007_BL 1.724040 0.01054052
## PTLG008_BL 1.729863 -0.02414209
## CD16+CD56-NKcells_ERK_IL100 CD4+Tcells_mem_ERK_IL100
## PTLG002_BL 0.5017782 0.001980188
## PTLG003_BL 0.8162624 0.040697062
## PTLG004_BL 1.1532978 0.087128774
## PTLG005_BL 0.5448805 0.028279407
## PTLG007_BL 0.8667597 0.027259055
## PTLG008_BL 0.4821994 0.060278715
## CD4+Tcells_naive_ERK_IL100 CD4+Tcells_ERK_IL100
## PTLG002_BL -0.02529154 -0.006767393
## PTLG003_BL -0.02091057 0.019518866
## PTLG004_BL -0.01537740 0.047082156
## PTLG005_BL 0.00398963 0.012984016
## PTLG007_BL 0.01508464 0.022446007
## PTLG008_BL 0.01779436 0.049181456
## CD45RA+Tregs_ERK_IL100 CD45RA-Tregs_ERK_IL100
## PTLG002_BL 0.04076368 -0.003790391
## PTLG003_BL 0.03588799 0.036843636
## PTLG004_BL -0.02729758 -0.029226943
## PTLG005_BL 0.01255565 0.032791105
## PTLG007_BL 0.05796270 0.056538932
## PTLG008_BL 0.03700298 0.079658894
## CD56+CD16-NKcells_ERK_IL100 CD7+NKcells_ERK_IL100
## PTLG002_BL 1.466490 0.6328631
## PTLG003_BL 1.593625 0.8557783
## PTLG004_BL 1.449741 1.0360217
## PTLG005_BL 1.351193 0.5893691
## PTLG007_BL 1.523448 0.8726131
## PTLG008_BL 1.717933 0.5588017
## CD8+Tcells_mem_ERK_IL100 CD8+Tcells_naive_ERK_IL100
## PTLG002_BL 0.2608020 0.081098431
## PTLG003_BL 0.4167038 0.167802216
## PTLG004_BL 0.4932712 0.009902669
## PTLG005_BL 0.2644027 0.023550487
## PTLG007_BL 0.3038282 0.318052197
## PTLG008_BL 0.2716617 0.092138296
## CD8+Tcells_ERK_IL100 cMCs_ERK_IL100 Gr_ERK_IL100
## PTLG002_BL 0.1863551 0.49326507 0.08302829
## PTLG003_BL 0.2614711 0.70751505 0.14789073
## PTLG004_BL 0.2384848 1.54479760 0.49134641
## PTLG005_BL 0.1310220 0.65382322 0.09912160
## PTLG007_BL 0.3146607 0.27160103 0.21822904
## PTLG008_BL 0.2072954 0.04776473 0.06300109
## intMCs_ERK_IL100 M-MDSC_ERK_IL100 mDCs_ERK_IL100
## PTLG002_BL 0.5812467 0.55470141 0.35095404
## PTLG003_BL 0.5598511 0.67323860 0.41838975
## PTLG004_BL 1.5286206 1.55760957 1.37329468
## PTLG005_BL 1.0215330 0.65574531 0.37064247
## PTLG007_BL 0.7576698 0.33554830 0.03053283
## PTLG008_BL 0.6033399 0.08945224 0.07272959
## ncMCs_ERK_IL100 pDCs_ERK_IL100 Tbet+CD4+Tcells_mem_ERK_IL100
## PTLG002_BL 0.04824813 0.21963297 0.08524395
## PTLG003_BL 0.32498934 0.16670304 0.17616455
## PTLG004_BL 0.54095549 0.29696647 0.22851867
## PTLG005_BL 0.46256008 0.08068998 0.05441359
## PTLG007_BL 0.90712724 0.09960886 0.08334648
## PTLG008_BL 0.49671749 0.20902656 0.17136406
## Tbet+CD4+Tcells_naive_ERK_IL100 Tbet+CD8+Tcells_mem_ERK_IL100
## PTLG002_BL 0.2919510 0.3204514
## PTLG003_BL 0.2477318 0.5920566
## PTLG004_BL 0.5914506 0.7120609
## PTLG005_BL 0.3797118 0.3478574
## PTLG007_BL 0.4412745 0.4516087
## PTLG008_BL 0.3255439 0.3609476
## Tbet+CD8+Tcells_naive_ERK_IL100 TCRgd+Tcells_ERK_IL100
## PTLG002_BL 0.4673205 0.3487545
## PTLG003_BL 0.5505320 0.8193163
## PTLG004_BL 0.6426220 1.0873612
## PTLG005_BL 0.2361545 0.4160448
## PTLG007_BL 0.5691801 0.7547252
## PTLG008_BL 0.3219266 0.4296019
## Tregs_ERK_IL100 Bcells_STAT1_IL100
## PTLG002_BL -0.002663823 0.2395953
## PTLG003_BL 0.037917415 0.1598883
## PTLG004_BL -0.026976770 0.2358010
## PTLG005_BL 0.011078611 0.1037533
## PTLG007_BL 0.054395346 0.1101323
## PTLG008_BL 0.075941970 0.1209797
## CD16+CD56-NKcells_STAT1_IL100 CD4+Tcells_mem_STAT1_IL100
## PTLG002_BL 0.16348543 1.0305536
## PTLG003_BL 0.20238788 1.0315348
## PTLG004_BL 0.37637866 0.9169553
## PTLG005_BL 0.09769525 0.8139722
## PTLG007_BL 0.11042592 0.7439470
## PTLG008_BL 0.07984131 0.9087509
## CD4+Tcells_naive_STAT1_IL100 CD4+Tcells_STAT1_IL100
## PTLG002_BL 1.790353 1.2833408
## PTLG003_BL 1.722792 1.2702308
## PTLG004_BL 1.632308 1.1858182
## PTLG005_BL 1.254344 1.0988459
## PTLG007_BL 1.230547 0.9196233
## PTLG008_BL 1.697326 1.1359749
## CD45RA+Tregs_STAT1_IL100 CD45RA-Tregs_STAT1_IL100
## PTLG002_BL 1.0496766 0.9523201
## PTLG003_BL 1.0317521 0.9626436
## PTLG004_BL 0.9141909 0.9525225
## PTLG005_BL 0.7442665 0.7666832
## PTLG007_BL 0.6851043 0.8161182
## PTLG008_BL 1.0296112 0.7633486
## CD56+CD16-NKcells_STAT1_IL100 CD7+NKcells_STAT1_IL100
## PTLG002_BL 0.5689056 0.2240150
## PTLG003_BL 0.5416451 0.2344680
## PTLG004_BL 0.7370061 0.2855482
## PTLG005_BL 0.3368075 0.1159681
## PTLG007_BL 0.4685141 0.1368052
## PTLG008_BL 0.4254796 0.1063011
## CD8+Tcells_mem_STAT1_IL100 CD8+Tcells_naive_STAT1_IL100
## PTLG002_BL 0.2837194 1.1884136
## PTLG003_BL 0.3655814 0.9746334
## PTLG004_BL 0.4263471 1.4710208
## PTLG005_BL 0.1499633 0.8144214
## PTLG007_BL 0.2124509 0.4142098
## PTLG008_BL 0.2054519 0.9232063
## CD8+Tcells_STAT1_IL100 cMCs_STAT1_IL100 Gr_STAT1_IL100
## PTLG002_BL 0.6641563 1.2479407 0.09727204
## PTLG003_BL 0.7458821 1.4790945 0.15231487
## PTLG004_BL 0.9771483 1.8594184 0.13635961
## PTLG005_BL 0.5144456 0.9411220 0.04939065
## PTLG007_BL 0.3043413 0.8895655 0.09122058
## PTLG008_BL 0.4586641 0.7200955 0.06882428
## intMCs_STAT1_IL100 M-MDSC_STAT1_IL100 mDCs_STAT1_IL100
## PTLG002_BL 0.8345070 1.2476217 0.8862378
## PTLG003_BL 1.0594639 1.3507359 0.9880019
## PTLG004_BL 1.8313334 1.9365056 1.3272223
## PTLG005_BL 0.6694916 0.9881290 0.5363834
## PTLG007_BL 0.6907539 0.9615591 0.5832657
## PTLG008_BL 0.4427145 0.6964223 0.5289693
## ncMCs_STAT1_IL100 pDCs_STAT1_IL100
## PTLG002_BL 0.1668810 0.6447603
## PTLG003_BL 0.2872139 0.6349425
## PTLG004_BL 0.1378978 1.1726577
## PTLG005_BL 0.1750241 0.2156090
## PTLG007_BL 0.1840795 0.4914381
## PTLG008_BL 0.1769595 0.4001473
## Tbet+CD4+Tcells_mem_STAT1_IL100
## PTLG002_BL 0.5956778
## PTLG003_BL 0.6671148
## PTLG004_BL 0.5164211
## PTLG005_BL 0.5910468
## PTLG007_BL 0.4859301
## PTLG008_BL 0.6216235
## Tbet+CD4+Tcells_naive_STAT1_IL100
## PTLG002_BL 0.9775717
## PTLG003_BL 0.5626643
## PTLG004_BL 1.0831281
## PTLG005_BL 1.1022829
## PTLG007_BL 0.8395405
## PTLG008_BL 1.1467345
## Tbet+CD8+Tcells_mem_STAT1_IL100
## PTLG002_BL 0.1966417
## PTLG003_BL 0.2565379
## PTLG004_BL 0.3019831
## PTLG005_BL 0.1063076
## PTLG007_BL 0.1019475
## PTLG008_BL 0.1080118
## Tbet+CD8+Tcells_naive_STAT1_IL100 TCRgd+Tcells_STAT1_IL100
## PTLG002_BL 0.15550917 0.24980144
## PTLG003_BL 0.15899914 0.27843610
## PTLG004_BL 0.40468451 0.29619562
## PTLG005_BL 0.12230364 0.12019859
## PTLG007_BL 0.07649342 0.09983393
## PTLG008_BL 0.08642774 0.10747571
## Tregs_STAT1_IL100 Bcells_STAT3_IL100
## PTLG002_BL 0.9499022 0.5926661
## PTLG003_BL 0.9573398 0.3995269
## PTLG004_BL 0.9462827 0.3299872
## PTLG005_BL 0.7514386 0.3581412
## PTLG007_BL 0.8046428 0.3906252
## PTLG008_BL 0.7758609 0.4332308
## CD16+CD56-NKcells_STAT3_IL100 CD4+Tcells_mem_STAT3_IL100
## PTLG002_BL 0.3960812 2.053836
## PTLG003_BL 0.3347897 1.908376
## PTLG004_BL 0.4118182 1.612510
## PTLG005_BL 0.2460617 2.000842
## PTLG007_BL 0.2325240 1.796922
## PTLG008_BL 0.2162920 1.657843
## CD4+Tcells_naive_STAT3_IL100 CD4+Tcells_STAT3_IL100
## PTLG002_BL 2.269259 2.124980
## PTLG003_BL 2.016883 1.945915
## PTLG004_BL 1.962275 1.742557
## PTLG005_BL 2.182828 2.119044
## PTLG007_BL 1.905684 1.835691
## PTLG008_BL 1.696692 1.670309
## CD45RA+Tregs_STAT3_IL100 CD45RA-Tregs_STAT3_IL100
## PTLG002_BL 2.020992 1.794446
## PTLG003_BL 1.911368 1.658424
## PTLG004_BL 1.751629 1.507646
## PTLG005_BL 1.988284 1.740357
## PTLG007_BL 1.786413 1.521907
## PTLG008_BL 1.643127 1.465620
## CD56+CD16-NKcells_STAT3_IL100 CD7+NKcells_STAT3_IL100
## PTLG002_BL 0.8822720 0.4962407
## PTLG003_BL 0.8142312 0.3948746
## PTLG004_BL 0.6712970 0.3404501
## PTLG005_BL 0.6793641 0.2941397
## PTLG007_BL 0.7013305 0.3022991
## PTLG008_BL 0.6362252 0.2610172
## CD8+Tcells_mem_STAT3_IL100 CD8+Tcells_naive_STAT3_IL100
## PTLG002_BL 0.8693999 1.8706207
## PTLG003_BL 0.8655054 1.4590036
## PTLG004_BL 0.7873105 1.9791174
## PTLG005_BL 0.6071679 1.8991410
## PTLG007_BL 0.6549356 0.8787849
## PTLG008_BL 0.6353154 1.3203225
## CD8+Tcells_STAT3_IL100 cMCs_STAT3_IL100 Gr_STAT3_IL100
## PTLG002_BL 1.2886604 2.792738 0.7200121
## PTLG003_BL 1.2337297 2.703599 0.7953590
## PTLG004_BL 1.4150953 2.628698 0.2810780
## PTLG005_BL 1.3146878 2.655494 0.4798248
## PTLG007_BL 0.7528307 2.360868 0.4514897
## PTLG008_BL 0.8756156 2.165407 0.3938240
## intMCs_STAT3_IL100 M-MDSC_STAT3_IL100 mDCs_STAT3_IL100
## PTLG002_BL 2.326279 2.842795 2.453799
## PTLG003_BL 2.319817 2.701811 2.278728
## PTLG004_BL 2.373751 2.582740 2.233316
## PTLG005_BL 2.256333 2.693906 2.054045
## PTLG007_BL 1.892205 2.420886 1.922163
## PTLG008_BL 1.443718 2.203052 1.764477
## ncMCs_STAT3_IL100 pDCs_STAT3_IL100
## PTLG002_BL 1.3883783 2.586926
## PTLG003_BL 1.2899382 2.453399
## PTLG004_BL 0.7041160 2.478023
## PTLG005_BL 1.3540980 2.076524
## PTLG007_BL 0.8205824 2.263891
## PTLG008_BL 0.8055951 2.120495
## Tbet+CD4+Tcells_mem_STAT3_IL100
## PTLG002_BL 1.618937
## PTLG003_BL 1.661021
## PTLG004_BL 1.115886
## PTLG005_BL 1.792288
## PTLG007_BL 1.448666
## PTLG008_BL 1.522800
## Tbet+CD4+Tcells_naive_STAT3_IL100
## PTLG002_BL 1.477918
## PTLG003_BL 1.032364
## PTLG004_BL 1.498180
## PTLG005_BL 2.005625
## PTLG007_BL 1.412778
## PTLG008_BL 1.595287
## Tbet+CD8+Tcells_mem_STAT3_IL100
## PTLG002_BL 0.6271236
## PTLG003_BL 0.6119127
## PTLG004_BL 0.5341346
## PTLG005_BL 0.4290052
## PTLG007_BL 0.3207057
## PTLG008_BL 0.3849628
## Tbet+CD8+Tcells_naive_STAT3_IL100 TCRgd+Tcells_STAT3_IL100
## PTLG002_BL 0.3477619 0.7144197
## PTLG003_BL 0.3306480 0.5026466
## PTLG004_BL 0.5434753 0.3997995
## PTLG005_BL 0.4659108 0.3951609
## PTLG007_BL 0.1858928 0.2505209
## PTLG008_BL 0.1941666 0.2572802
## Tregs_STAT3_IL100 Bcells_STAT5_IL100
## PTLG002_BL 1.803272 0.7011217
## PTLG003_BL 1.697154 0.4877259
## PTLG004_BL 1.546490 0.3559880
## PTLG005_BL 1.817593 0.4188459
## PTLG007_BL 1.562735 0.4145982
## PTLG008_BL 1.473305 0.4703189
## CD16+CD56-NKcells_STAT5_IL100 CD4+Tcells_mem_STAT5_IL100
## PTLG002_BL 1.714196 2.281618
## PTLG003_BL 1.642010 2.170205
## PTLG004_BL 1.635373 2.168798
## PTLG005_BL 1.478672 2.237117
## PTLG007_BL 1.598285 2.139578
## PTLG008_BL 1.401682 2.140262
## CD4+Tcells_naive_STAT5_IL100 CD4+Tcells_STAT5_IL100
## PTLG002_BL 1.582466 2.054797
## PTLG003_BL 1.560734 1.962617
## PTLG004_BL 1.302549 1.847129
## PTLG005_BL 1.581244 1.815020
## PTLG007_BL 1.603671 1.947819
## PTLG008_BL 1.616702 1.990917
## CD45RA+Tregs_STAT5_IL100 CD45RA-Tregs_STAT5_IL100
## PTLG002_BL 1.993828 2.399908
## PTLG003_BL 1.981066 2.308622
## PTLG004_BL 1.809791 2.330400
## PTLG005_BL 2.019320 2.352912
## PTLG007_BL 1.921229 2.279483
## PTLG008_BL 1.855102 2.228603
## CD56+CD16-NKcells_STAT5_IL100 CD7+NKcells_STAT5_IL100
## PTLG002_BL 2.046668 1.755906
## PTLG003_BL 1.859863 1.629905
## PTLG004_BL 1.951974 1.782189
## PTLG005_BL 1.739758 1.486918
## PTLG007_BL 1.898545 1.593184
## PTLG008_BL 1.775762 1.422303
## CD8+Tcells_mem_STAT5_IL100 CD8+Tcells_naive_STAT5_IL100
## PTLG002_BL 2.231609 1.971236
## PTLG003_BL 2.185057 1.868441
## PTLG004_BL 2.196968 1.722882
## PTLG005_BL 2.138116 1.829757
## PTLG007_BL 1.953263 1.729812
## PTLG008_BL 2.045576 1.770191
## CD8+Tcells_STAT5_IL100 cMCs_STAT5_IL100 Gr_STAT5_IL100
## PTLG002_BL 2.120877 0.8600174 0.4962128
## PTLG003_BL 1.984899 0.8563645 0.5364788
## PTLG004_BL 1.947343 0.9402423 0.4102355
## PTLG005_BL 1.967395 0.5600075 0.2558830
## PTLG007_BL 1.845892 0.7620188 0.5046695
## PTLG008_BL 1.946993 0.7711462 0.5227776
## intMCs_STAT5_IL100 M-MDSC_STAT5_IL100 mDCs_STAT5_IL100
## PTLG002_BL 0.3469080 0.8864489 0.8689818
## PTLG003_BL 0.4784145 0.7908422 0.7970713
## PTLG004_BL 0.6665875 0.9736109 0.7550490
## PTLG005_BL 0.2222515 0.5718071 0.6025084
## PTLG007_BL 0.4347463 0.7527192 0.7894664
## PTLG008_BL 0.3955707 0.7283706 0.7883751
## ncMCs_STAT5_IL100 pDCs_STAT5_IL100
## PTLG002_BL 0.1100864 0.2849853
## PTLG003_BL 0.1983204 0.2811485
## PTLG004_BL -0.1232073 0.3579064
## PTLG005_BL 0.1193339 0.2418733
## PTLG007_BL 0.8275516 0.2160641
## PTLG008_BL 0.2444194 0.2205434
## Tbet+CD4+Tcells_mem_STAT5_IL100
## PTLG002_BL 2.345900
## PTLG003_BL 2.299712
## PTLG004_BL 2.217856
## PTLG005_BL 2.291926
## PTLG007_BL 2.154726
## PTLG008_BL 2.267952
## Tbet+CD4+Tcells_naive_STAT5_IL100
## PTLG002_BL 1.854001
## PTLG003_BL 2.137430
## PTLG004_BL 1.652032
## PTLG005_BL 2.008314
## PTLG007_BL 1.972845
## PTLG008_BL 1.869471
## Tbet+CD8+Tcells_mem_STAT5_IL100
## PTLG002_BL 2.206734
## PTLG003_BL 2.220906
## PTLG004_BL 2.203724
## PTLG005_BL 2.166904
## PTLG007_BL 1.863833
## PTLG008_BL 2.051340
## Tbet+CD8+Tcells_naive_STAT5_IL100 TCRgd+Tcells_STAT5_IL100
## PTLG002_BL 2.094353 2.387055
## PTLG003_BL 1.995188 2.313756
## PTLG004_BL 2.002730 2.282475
## PTLG005_BL 2.096962 2.179530
## PTLG007_BL 1.734590 1.915468
## PTLG008_BL 1.804932 2.087163
## Tregs_STAT5_IL100 CD16+CD56-NKcells_CREB_LPS100
## PTLG002_BL 2.384089 -0.20549591
## PTLG003_BL 2.279947 -0.24007337
## PTLG004_BL 2.285439 0.03541109
## PTLG005_BL 2.265718 -0.19477639
## PTLG007_BL 2.260803 -0.23369030
## PTLG008_BL 2.200156 -0.25023098
## CD45RA+Tregs_CREB_LPS100 CD45RA-Tregs_CREB_LPS100
## PTLG002_BL 0.14101744 -0.02258818
## PTLG003_BL -0.02904165 -0.06543320
## PTLG004_BL 0.11152327 0.03047517
## PTLG005_BL -0.18264177 -0.09134030
## PTLG007_BL -0.02596627 -0.08639733
## PTLG008_BL -0.01484645 -0.09125998
## CD56+CD16-NKcells_CREB_LPS100 CD7+NKcells_CREB_LPS100
## PTLG002_BL -0.19698643 -0.20694000
## PTLG003_BL -0.20401176 -0.23808100
## PTLG004_BL -0.03997293 0.02027633
## PTLG005_BL -0.09335936 -0.18792888
## PTLG007_BL -0.17047064 -0.22249073
## PTLG008_BL -0.14379741 -0.23444290
## cMCs_CREB_LPS100 Gr_CREB_LPS100 intMCs_CREB_LPS100
## PTLG002_BL 0.34311428 0.5805528 0.4987125
## PTLG003_BL 0.19051762 0.6445924 0.5591770
## PTLG004_BL 1.08836610 0.6821470 0.7478204
## PTLG005_BL 0.36612317 0.7933054 0.6840124
## PTLG007_BL 0.01994862 0.2317707 0.4824301
## PTLG008_BL 0.09295563 0.2721102 0.6550964
## M-MDSC_CREB_LPS100 mDCs_CREB_LPS100 ncMCs_CREB_LPS100
## PTLG002_BL 0.355938946 0.4403483 0.5127153
## PTLG003_BL 0.180190575 0.1398782 0.8618568
## PTLG004_BL 1.147967408 1.2907507 0.2873403
## PTLG005_BL 0.374450213 0.4188072 0.8347602
## PTLG007_BL 0.003738333 0.0376083 0.4525493
## PTLG008_BL 0.080292173 0.1370246 0.7710514
## Tregs_CREB_LPS100 CD16+CD56-NKcells_ERK_LPS100
## PTLG002_BL -0.007856718 0.016152511
## PTLG003_BL -0.068201575 0.010354332
## PTLG004_BL 0.050400780 0.064435013
## PTLG005_BL -0.122439006 0.016047944
## PTLG007_BL -0.081816516 0.009141602
## PTLG008_BL -0.088285815 0.016829029
## CD45RA+Tregs_ERK_LPS100 CD45RA-Tregs_ERK_LPS100
## PTLG002_BL 0.21275586 0.011584249
## PTLG003_BL 0.04996624 0.016911116
## PTLG004_BL 0.15415303 0.010625294
## PTLG005_BL 0.03451567 0.021459485
## PTLG007_BL 0.05751801 0.007061585
## PTLG008_BL 0.15036254 0.037874990
## CD56+CD16-NKcells_ERK_LPS100 CD7+NKcells_ERK_LPS100
## PTLG002_BL 0.013630501 0.011272548
## PTLG003_BL -0.007431743 0.010163186
## PTLG004_BL 0.052309381 0.032660647
## PTLG005_BL 0.029539137 0.017668474
## PTLG007_BL 0.012696146 0.009381648
## PTLG008_BL 0.018199712 0.019601785
## cMCs_ERK_LPS100 Gr_ERK_LPS100 intMCs_ERK_LPS100
## PTLG002_BL 1.952365 0.7105355 2.357536
## PTLG003_BL 1.947608 0.6906589 2.744057
## PTLG004_BL 2.505529 0.7821723 1.793900
## PTLG005_BL 1.618730 0.5362286 2.834057
## PTLG007_BL 1.532323 0.4562182 2.454769
## PTLG008_BL 1.440713 0.3029513 2.547342
## M-MDSC_ERK_LPS100 mDCs_ERK_LPS100 ncMCs_ERK_LPS100
## PTLG002_BL 1.545121 2.109581 2.2881374
## PTLG003_BL 1.354133 1.926142 2.6029729
## PTLG004_BL 2.299557 2.884207 0.8922558
## PTLG005_BL 1.466717 1.577241 2.3744848
## PTLG007_BL 1.319185 1.432937 1.5413898
## PTLG008_BL 1.284307 1.620961 2.3470461
## Tregs_ERK_LPS100 CD16+CD56-NKcells_IkB_LPS100
## PTLG002_BL 0.023125687 0.20935688
## PTLG003_BL 0.009697132 0.09438654
## PTLG004_BL 0.032942748 -0.03590278
## PTLG005_BL 0.006859739 0.08113436
## PTLG007_BL 0.015756620 0.04732308
## PTLG008_BL 0.054177064 -0.03328707
## CD45RA+Tregs_IkB_LPS100 CD45RA-Tregs_IkB_LPS100
## PTLG002_BL 0.147008659 0.08926275
## PTLG003_BL 0.037887028 0.06314613
## PTLG004_BL 0.034595435 0.03134623
## PTLG005_BL 0.058084646 0.04001207
## PTLG007_BL -0.009040269 -0.02074935
## PTLG008_BL -0.107405057 -0.07581595
## CD56+CD16-NKcells_IkB_LPS100 CD7+NKcells_IkB_LPS100
## PTLG002_BL 0.0087090416 0.18057942
## PTLG003_BL 0.0007324463 0.08200923
## PTLG004_BL 0.0809355129 0.05945091
## PTLG005_BL 0.0083451860 0.07440806
## PTLG007_BL 0.0170060204 0.03826008
## PTLG008_BL -0.0396878589 -0.03546267
## cMCs_IkB_LPS100 Gr_IkB_LPS100 intMCs_IkB_LPS100
## PTLG002_BL -0.6440885 -0.2302899 -0.1907484
## PTLG003_BL -0.9613265 -0.3033193 -0.5541598
## PTLG004_BL -0.9722093 -0.3498934 -0.5976991
## PTLG005_BL -0.5389036 -0.2655422 -0.1378193
## PTLG007_BL -0.9801520 -0.3273486 -0.4397723
## PTLG008_BL -1.0142779 -0.3176060 -0.5733044
## M-MDSC_IkB_LPS100 mDCs_IkB_LPS100 ncMCs_IkB_LPS100
## PTLG002_BL -0.4959364 -0.7385616 -0.1652233
## PTLG003_BL -0.6746312 -0.9700044 -0.2910204
## PTLG004_BL -0.9907348 -0.9049838 -0.4379260
## PTLG005_BL -0.5076983 -0.7130436 -0.1044108
## PTLG007_BL -0.8899128 -0.9619267 -0.1750182
## PTLG008_BL -0.9750332 -0.9744760 -0.4094405
## Tregs_IkB_LPS100 CD16+CD56-NKcells_MAPKAPK2_LPS100
## PTLG002_BL 0.09687828 0.04511100
## PTLG003_BL 0.05556787 0.05027454
## PTLG004_BL 0.03257948 -0.02766143
## PTLG005_BL 0.04757067 -0.02178715
## PTLG007_BL -0.01041354 0.16100935
## PTLG008_BL -0.07330581 0.15937056
## CD45RA+Tregs_MAPKAPK2_LPS100 CD45RA-Tregs_MAPKAPK2_LPS100
## PTLG002_BL 0.198207032 0.03576117
## PTLG003_BL 0.123005603 0.03026736
## PTLG004_BL 0.052514476 0.02527546
## PTLG005_BL 0.006451273 -0.03447481
## PTLG007_BL 0.199329107 0.07715373
## PTLG008_BL 0.228357561 0.10363110
## CD56+CD16-NKcells_MAPKAPK2_LPS100 CD7+NKcells_MAPKAPK2_LPS100
## PTLG002_BL 0.06349375 0.054902287
## PTLG003_BL 0.07480528 0.053145328
## PTLG004_BL 0.01335489 0.004631184
## PTLG005_BL -0.01944893 -0.016860306
## PTLG007_BL 0.13451775 0.149682085
## PTLG008_BL 0.13743886 0.152431080
## cMCs_MAPKAPK2_LPS100 Gr_MAPKAPK2_LPS100 intMCs_MAPKAPK2_LPS100
## PTLG002_BL 1.390856 1.4384043 1.2704791
## PTLG003_BL 1.076334 1.0924306 1.1709347
## PTLG004_BL 1.493018 1.3016543 0.7069185
## PTLG005_BL 1.189113 1.0182068 1.2345900
## PTLG007_BL 1.135641 0.6403859 1.2165069
## PTLG008_BL 1.267801 0.4958583 1.2541071
## M-MDSC_MAPKAPK2_LPS100 mDCs_MAPKAPK2_LPS100
## PTLG002_BL 1.612364 1.1631356
## PTLG003_BL 1.249096 0.8483572
## PTLG004_BL 1.614831 1.3298613
## PTLG005_BL 1.269358 0.8148355
## PTLG007_BL 1.282972 0.8139966
## PTLG008_BL 1.424968 1.0587535
## ncMCs_MAPKAPK2_LPS100 Tregs_MAPKAPK2_LPS100
## PTLG002_BL 1.1476445 0.04973764
## PTLG003_BL 1.0967621 0.03588095
## PTLG004_BL 0.1797037 0.04180874
## PTLG005_BL 1.0737397 -0.02494619
## PTLG007_BL 0.6992199 0.09722564
## PTLG008_BL 1.2265420 0.12429454
## CD16+CD56-NKcells_NFkB_LPS100 CD45RA+Tregs_NFkB_LPS100
## PTLG002_BL 0.008981544 0.135162941
## PTLG003_BL 0.013206406 0.045235854
## PTLG004_BL 0.041123759 -0.002251015
## PTLG005_BL 0.129511446 0.100006664
## PTLG007_BL 0.010408951 -0.007787558
## PTLG008_BL 0.069148952 0.097103011
## CD45RA-Tregs_NFkB_LPS100 CD56+CD16-NKcells_NFkB_LPS100
## PTLG002_BL 0.088216413 0.057648798
## PTLG003_BL 0.020141135 -0.005536755
## PTLG004_BL 0.055342114 0.032336145
## PTLG005_BL 0.107277372 0.143304942
## PTLG007_BL -0.026552381 -0.035312063
## PTLG008_BL 0.004783363 0.045399839
## CD7+NKcells_NFkB_LPS100 cMCs_NFkB_LPS100 Gr_NFkB_LPS100
## PTLG002_BL 0.019419696 0.3648047 0.33611534
## PTLG003_BL 0.011138036 0.4213470 0.38582775
## PTLG004_BL 0.080394615 0.6894857 0.30083758
## PTLG005_BL 0.135780614 0.4507500 0.21994337
## PTLG007_BL 0.006049531 0.2994131 0.03598859
## PTLG008_BL 0.065476430 0.2972410 0.02955353
## intMCs_NFkB_LPS100 M-MDSC_NFkB_LPS100 mDCs_NFkB_LPS100
## PTLG002_BL 0.4908122 0.3021075 0.3889814
## PTLG003_BL 0.5635687 0.3498012 0.4316558
## PTLG004_BL 0.5164665 0.6723920 0.8059898
## PTLG005_BL 0.5992361 0.4197109 0.3743859
## PTLG007_BL 0.2744813 0.2607021 0.3251304
## PTLG008_BL 0.3897066 0.2931580 0.3726967
## ncMCs_NFkB_LPS100 Tregs_NFkB_LPS100
## PTLG002_BL 0.34094665 0.08899580
## PTLG003_BL 0.49365417 0.01698463
## PTLG004_BL 0.05811524 0.07530978
## PTLG005_BL 0.43242575 0.09756483
## PTLG007_BL 0.10831727 -0.02178815
## PTLG008_BL 0.31187626 0.01041033
## CD16+CD56-NKcells_p38_LPS100 CD45RA+Tregs_p38_LPS100
## PTLG002_BL 0.05785440 0.34482208
## PTLG003_BL 0.02286360 0.09349863
## PTLG004_BL 0.10826239 0.21527128
## PTLG005_BL 0.03997791 0.05885838
## PTLG007_BL -0.02837300 0.03645351
## PTLG008_BL -0.04266069 0.08485487
## CD45RA-Tregs_p38_LPS100 CD56+CD16-NKcells_p38_LPS100
## PTLG002_BL 0.08414393 0.0687725414
## PTLG003_BL 0.05550423 -0.0008153601
## PTLG004_BL 0.18456960 0.1031056577
## PTLG005_BL 0.03444131 0.0483402093
## PTLG007_BL -0.02399314 -0.0215372796
## PTLG008_BL -0.06657235 -0.0302015580
## CD7+NKcells_p38_LPS100 cMCs_p38_LPS100 Gr_p38_LPS100
## PTLG002_BL 0.05535226 2.339772 1.8325278
## PTLG003_BL 0.01980798 2.121308 1.5333925
## PTLG004_BL 0.13631143 3.181073 1.4790379
## PTLG005_BL 0.04279666 2.515220 1.3840292
## PTLG007_BL -0.02389599 1.911470 0.8923686
## PTLG008_BL -0.03817797 2.012627 0.7476081
## intMCs_p38_LPS100 M-MDSC_p38_LPS100 mDCs_p38_LPS100
## PTLG002_BL 2.221253 2.528309 2.073169
## PTLG003_BL 2.484656 2.202611 1.640924
## PTLG004_BL 2.172893 3.343664 3.018975
## PTLG005_BL 2.700767 2.646864 1.923198
## PTLG007_BL 2.467112 2.060119 1.327613
## PTLG008_BL 2.308486 2.205805 1.702619
## ncMCs_p38_LPS100 Tregs_p38_LPS100 CD16+CD56-NKcells_S6_LPS100
## PTLG002_BL 2.193294 0.09463160 -0.09683664
## PTLG003_BL 2.458356 0.05061225 -0.07219161
## PTLG004_BL 1.329431 0.20012863 -0.15223728
## PTLG005_BL 2.492425 0.03674702 -0.12277477
## PTLG007_BL 1.439619 -0.01842348 -0.14723229
## PTLG008_BL 2.268346 -0.04567228 -0.04269478
## CD45RA+Tregs_S6_LPS100 CD45RA-Tregs_S6_LPS100
## PTLG002_BL 0.101151718 -0.030496912
## PTLG003_BL -0.035906346 -0.028808484
## PTLG004_BL -0.009167584 0.018029851
## PTLG005_BL -0.054452495 -0.020934690
## PTLG007_BL -0.017929046 -0.009322776
## PTLG008_BL 0.169234090 -0.005680856
## CD56+CD16-NKcells_S6_LPS100 CD7+NKcells_S6_LPS100
## PTLG002_BL -0.075554183 -0.10627246
## PTLG003_BL -0.023323562 -0.07618660
## PTLG004_BL -0.078897186 -0.07591937
## PTLG005_BL -0.002650045 -0.11862976
## PTLG007_BL -0.077534436 -0.13451729
## PTLG008_BL -0.029806256 -0.03963849
## cMCs_S6_LPS100 Gr_S6_LPS100 intMCs_S6_LPS100 M-MDSC_S6_LPS100
## PTLG002_BL 0.4292651 0.23223979 0.7613082 0.3682464
## PTLG003_BL 0.2273187 0.10189986 0.6070797 0.2196874
## PTLG004_BL 1.0864111 0.12479844 0.9084286 1.1694429
## PTLG005_BL 0.5082582 0.15151756 0.7968184 0.5436250
## PTLG007_BL 0.2231767 0.06822486 0.3708214 0.2601410
## PTLG008_BL 0.3051479 0.09561227 0.6837082 0.3455624
## mDCs_S6_LPS100 ncMCs_S6_LPS100 Tregs_S6_LPS100
## PTLG002_BL 0.5152369 0.3977881 -0.017765977
## PTLG003_BL 0.2346379 0.5020941 -0.032820965
## PTLG004_BL 1.0364160 0.1701248 0.016324160
## PTLG005_BL 0.4841948 0.4370171 -0.032356324
## PTLG007_BL 0.3374240 0.1542708 -0.006793217
## PTLG008_BL 0.4051185 0.4110216 0.005905841
## Bcells_CREB_Unstim CD16+CD56-NKcells_CREB_Unstim
## PTLG002_BL 1.3433418 1.532027
## PTLG003_BL 0.9926098 1.508009
## PTLG004_BL 0.7210040 1.230525
## PTLG005_BL 1.0252745 1.453080
## PTLG007_BL 1.2571543 1.503886
## PTLG008_BL 1.8841074 1.678987
## CD4+Tcells_mem_CREB_Unstim CD4+Tcells_naive_CREB_Unstim
## PTLG002_BL 1.1997700 0.8457298
## PTLG003_BL 1.1211777 0.7980025
## PTLG004_BL 0.9310409 0.6724242
## PTLG005_BL 1.1772996 0.9531886
## PTLG007_BL 1.1855504 0.8468169
## PTLG008_BL 1.1955620 0.8363357
## CD4+Tcells_CREB_Unstim CD45RA+Tregs_CREB_Unstim
## PTLG002_BL 1.0834691 0.9875978
## PTLG003_BL 1.0093470 0.8475886
## PTLG004_BL 0.8284817 0.6658917
## PTLG005_BL 1.0331631 0.9625428
## PTLG007_BL 1.0613300 0.8990335
## PTLG008_BL 1.0941662 0.9879212
## CD45RA-Tregs_CREB_Unstim CD56+CD16-NKcells_CREB_Unstim
## PTLG002_BL 0.8324991 1.324453
## PTLG003_BL 0.8222516 1.138242
## PTLG004_BL 0.6671049 1.031497
## PTLG005_BL 0.8571139 1.191852
## PTLG007_BL 0.7922701 1.240526
## PTLG008_BL 0.9377368 1.320252
## CD7+NKcells_CREB_Unstim CD8+Tcells_mem_CREB_Unstim
## PTLG002_BL 1.488668 1.440155
## PTLG003_BL 1.475504 1.319915
## PTLG004_BL 1.071216 1.126430
## PTLG005_BL 1.428639 1.651728
## PTLG007_BL 1.462185 1.337312
## PTLG008_BL 1.637032 1.691526
## CD8+Tcells_naive_CREB_Unstim CD8+Tcells_CREB_Unstim
## PTLG002_BL 0.9334009 1.2252535
## PTLG003_BL 0.9386930 1.0757279
## PTLG004_BL 0.7315596 0.9178034
## PTLG005_BL 1.0734068 1.3281334
## PTLG007_BL 1.1040712 1.2260894
## PTLG008_BL 1.0715650 1.4708587
## cMCs_CREB_Unstim Gr_CREB_Unstim intMCs_CREB_Unstim
## PTLG002_BL 2.975155 1.793294 2.977520
## PTLG003_BL 3.294566 1.781407 3.031817
## PTLG004_BL 2.229590 1.472990 2.505138
## PTLG005_BL 3.043658 1.643267 2.879241
## PTLG007_BL 3.273960 1.833146 2.871442
## PTLG008_BL 3.192141 1.689530 2.583249
## M-MDSC_CREB_Unstim mDCs_CREB_Unstim ncMCs_CREB_Unstim
## PTLG002_BL 2.725288 2.835898 2.467263
## PTLG003_BL 3.073744 3.129188 2.297820
## PTLG004_BL 2.100119 2.012466 1.895854
## PTLG005_BL 2.952202 2.807560 2.401345
## PTLG007_BL 3.224531 3.082081 1.861059
## PTLG008_BL 3.108832 3.106337 2.156004
## pDCs_CREB_Unstim Tbet+CD4+Tcells_mem_CREB_Unstim
## PTLG002_BL 1.454832 1.415466
## PTLG003_BL 1.393917 1.359145
## PTLG004_BL 1.273837 1.126085
## PTLG005_BL 1.349529 1.377281
## PTLG007_BL 1.605210 1.346844
## PTLG008_BL 1.451530 1.439356
## Tbet+CD4+Tcells_naive_CREB_Unstim
## PTLG002_BL 1.568470
## PTLG003_BL 1.410527
## PTLG004_BL 1.655602
## PTLG005_BL 1.609416
## PTLG007_BL 1.630289
## PTLG008_BL 1.879834
## Tbet+CD8+Tcells_mem_CREB_Unstim
## PTLG002_BL 1.466800
## PTLG003_BL 1.377181
## PTLG004_BL 1.197759
## PTLG005_BL 1.749744
## PTLG007_BL 1.336534
## PTLG008_BL 1.791499
## Tbet+CD8+Tcells_naive_CREB_Unstim TCRgd+Tcells_CREB_Unstim
## PTLG002_BL 1.238467 1.742571
## PTLG003_BL 1.228972 1.614053
## PTLG004_BL 1.085852 1.328081
## PTLG005_BL 1.585154 1.623138
## PTLG007_BL 1.247040 1.395084
## PTLG008_BL 1.393658 1.798631
## Tregs_CREB_Unstim Bcells_ERK_Unstim
## PTLG002_BL 0.8420510 0.2672850
## PTLG003_BL 0.8314625 0.1493333
## PTLG004_BL 0.6612819 0.1437372
## PTLG005_BL 0.8899306 0.1389144
## PTLG007_BL 0.8099278 0.1518666
## PTLG008_BL 0.9452765 0.3844152
## CD16+CD56-NKcells_ERK_Unstim CD4+Tcells_mem_ERK_Unstim
## PTLG002_BL 0.1980417 0.5272692
## PTLG003_BL 0.1400068 0.4044905
## PTLG004_BL 0.2062540 0.3936610
## PTLG005_BL 0.1342514 0.4042180
## PTLG007_BL 0.1228718 0.3685582
## PTLG008_BL 0.1564059 0.4812678
## CD4+Tcells_naive_ERK_Unstim CD4+Tcells_ERK_Unstim
## PTLG002_BL 0.5836233 0.5454376
## PTLG003_BL 0.4753995 0.4288401
## PTLG004_BL 0.4365401 0.4112210
## PTLG005_BL 0.4384015 0.4256636
## PTLG007_BL 0.4062716 0.3821984
## PTLG008_BL 0.5217830 0.4921477
## CD45RA+Tregs_ERK_Unstim CD45RA-Tregs_ERK_Unstim
## PTLG002_BL 0.5812817 0.5692047
## PTLG003_BL 0.4554003 0.4023745
## PTLG004_BL 0.4114813 0.4435352
## PTLG005_BL 0.3950008 0.4010113
## PTLG007_BL 0.3835649 0.3528119
## PTLG008_BL 0.5329451 0.4888328
## CD56+CD16-NKcells_ERK_Unstim CD7+NKcells_ERK_Unstim
## PTLG002_BL 0.2074730 0.1987725
## PTLG003_BL 0.1327644 0.1405541
## PTLG004_BL 0.1559697 0.1454384
## PTLG005_BL 0.1241305 0.1345663
## PTLG007_BL 0.1342321 0.1238486
## PTLG008_BL 0.1577764 0.1559829
## CD8+Tcells_mem_ERK_Unstim CD8+Tcells_naive_ERK_Unstim
## PTLG002_BL 0.4762590 0.4914464
## PTLG003_BL 0.3445212 0.3714142
## PTLG004_BL 0.3690586 0.3897315
## PTLG005_BL 0.3647699 0.3923553
## PTLG007_BL 0.3024970 0.3077980
## PTLG008_BL 0.4297884 0.4428694
## CD8+Tcells_ERK_Unstim cMCs_ERK_Unstim Gr_ERK_Unstim
## PTLG002_BL 0.4822092 1.0197033 0.5898345
## PTLG003_BL 0.3612244 1.1321097 0.5148939
## PTLG004_BL 0.3796295 0.5450609 0.3041530
## PTLG005_BL 0.3803104 0.6524384 0.2986586
## PTLG007_BL 0.3052909 1.4486824 0.5565627
## PTLG008_BL 0.4343754 1.5321937 0.4912841
## intMCs_ERK_Unstim M-MDSC_ERK_Unstim mDCs_ERK_Unstim
## PTLG002_BL 1.3154473 0.9753772 0.6300807
## PTLG003_BL 1.1246179 1.2282288 0.5673900
## PTLG004_BL 1.0497173 0.4393444 0.4266768
## PTLG005_BL 0.6394464 0.6184404 0.3759113
## PTLG007_BL 1.3156914 1.5618929 0.7633571
## PTLG008_BL 0.8632018 1.5335981 0.9022041
## ncMCs_ERK_Unstim pDCs_ERK_Unstim Tbet+CD4+Tcells_mem_ERK_Unstim
## PTLG002_BL 0.8102725 0.2404294 0.5277215
## PTLG003_BL 0.6132274 0.1925976 0.3969733
## PTLG004_BL 0.8543679 0.2220316 0.3977953
## PTLG005_BL 0.3694352 0.1973168 0.4111924
## PTLG007_BL 0.5666094 0.2051224 0.3514124
## PTLG008_BL 0.3618514 0.2016478 0.4916257
## Tbet+CD4+Tcells_naive_ERK_Unstim Tbet+CD8+Tcells_mem_ERK_Unstim
## PTLG002_BL 0.6447991 0.4706652
## PTLG003_BL 0.4658451 0.3428644
## PTLG004_BL 0.6809092 0.3658209
## PTLG005_BL 0.5367616 0.3742293
## PTLG007_BL 0.5120548 0.2911482
## PTLG008_BL 0.7494313 0.4329718
## Tbet+CD8+Tcells_naive_ERK_Unstim TCRgd+Tcells_ERK_Unstim
## PTLG002_BL 0.4443277 0.6725423
## PTLG003_BL 0.3134304 0.5029932
## PTLG004_BL 0.3227723 0.4860715
## PTLG005_BL 0.3568750 0.5077049
## PTLG007_BL 0.2847943 0.3730116
## PTLG008_BL 0.3952785 0.5810769
## Tregs_ERK_Unstim Bcells_IkB_Unstim CD16+CD56-NKcells_IkB_Unstim
## PTLG002_BL 0.5707442 0.4957551 0.5811274
## PTLG003_BL 0.4127159 0.6110090 0.9202951
## PTLG004_BL 0.4370240 0.7153698 0.9087945
## PTLG005_BL 0.4119755 0.5029687 0.5923683
## PTLG007_BL 0.3581861 0.8040305 1.0196055
## PTLG008_BL 0.4926159 0.4517800 0.9258562
## CD4+Tcells_mem_IkB_Unstim CD4+Tcells_naive_IkB_Unstim
## PTLG002_BL 1.0146019 1.163821
## PTLG003_BL 1.1504247 1.254549
## PTLG004_BL 1.0908865 1.162310
## PTLG005_BL 0.8809294 1.018979
## PTLG007_BL 1.4665071 1.557427
## PTLG008_BL 1.3455708 1.560146
## CD4+Tcells_IkB_Unstim CD45RA+Tregs_IkB_Unstim
## PTLG002_BL 1.0633810 0.9892565
## PTLG003_BL 1.1861295 1.0765872
## PTLG004_BL 1.1192682 1.0075626
## PTLG005_BL 0.9698752 0.8199048
## PTLG007_BL 1.4991030 1.2773247
## PTLG008_BL 1.4050642 1.3772634
## CD45RA-Tregs_IkB_Unstim CD56+CD16-NKcells_IkB_Unstim
## PTLG002_BL 0.7094038 1.0103343
## PTLG003_BL 0.8766380 1.1034579
## PTLG004_BL 0.8425829 0.9517444
## PTLG005_BL 0.6440883 0.8353730
## PTLG007_BL 1.0523057 1.3177363
## PTLG008_BL 1.0320232 1.1445781
## CD7+NKcells_IkB_Unstim CD8+Tcells_mem_IkB_Unstim
## PTLG002_BL 0.6448355 0.7923299
## PTLG003_BL 0.9328354 0.9311403
## PTLG004_BL 0.8435762 1.0063048
## PTLG005_BL 0.6133572 0.8126160
## PTLG007_BL 1.0420709 1.1496628
## PTLG008_BL 0.9392652 1.2138526
## CD8+Tcells_naive_IkB_Unstim CD8+Tcells_IkB_Unstim
## PTLG002_BL 1.188597 0.9583476
## PTLG003_BL 1.131707 1.0586876
## PTLG004_BL 1.409275 1.2190665
## PTLG005_BL 1.119142 0.9835524
## PTLG007_BL 1.220997 1.1814683
## PTLG008_BL 1.490771 1.3094550
## cMCs_IkB_Unstim Gr_IkB_Unstim intMCs_IkB_Unstim
## PTLG002_BL 0.9492812 0.4692803 0.5001521
## PTLG003_BL 1.2997187 0.4989642 0.7791884
## PTLG004_BL 1.2388791 0.5913544 1.0760914
## PTLG005_BL 0.7735298 0.4594367 0.3034238
## PTLG007_BL 1.3727226 0.6535002 0.6138219
## PTLG008_BL 1.3057210 0.6160794 0.7690030
## M-MDSC_IkB_Unstim mDCs_IkB_Unstim ncMCs_IkB_Unstim
## PTLG002_BL 0.7607700 1.177284 0.3031295
## PTLG003_BL 0.9426775 1.583643 0.4271982
## PTLG004_BL 1.2511315 1.191102 0.6629044
## PTLG005_BL 0.7214756 1.199609 0.2060941
## PTLG007_BL 1.2053061 1.754071 0.5821034
## PTLG008_BL 1.2089865 1.463681 0.5379507
## pDCs_IkB_Unstim Tbet+CD4+Tcells_mem_IkB_Unstim
## PTLG002_BL 1.469599 0.8766546
## PTLG003_BL 1.472385 1.1094269
## PTLG004_BL 1.266636 1.0811471
## PTLG005_BL 1.239865 0.8679350
## PTLG007_BL 1.635122 1.4088745
## PTLG008_BL 1.500683 1.2728972
## Tbet+CD4+Tcells_naive_IkB_Unstim Tbet+CD8+Tcells_mem_IkB_Unstim
## PTLG002_BL 1.035477 0.7079507
## PTLG003_BL 1.166272 0.8880699
## PTLG004_BL 1.428714 0.9696454
## PTLG005_BL 1.077304 0.8101481
## PTLG007_BL 1.687358 1.0083487
## PTLG008_BL 1.714373 1.1539838
## Tbet+CD8+Tcells_naive_IkB_Unstim TCRgd+Tcells_IkB_Unstim
## PTLG002_BL 0.5979821 0.7761091
## PTLG003_BL 0.7795676 0.9839934
## PTLG004_BL 0.9708966 1.0102838
## PTLG005_BL 0.7988405 0.7616490
## PTLG007_BL 0.8815053 1.0307880
## PTLG008_BL 0.9011593 1.1006550
## Tregs_IkB_Unstim Bcells_MAPKAPK2_Unstim
## PTLG002_BL 0.7233968 2.311810
## PTLG003_BL 0.9024052 2.596986
## PTLG004_BL 0.8572894 2.549688
## PTLG005_BL 0.7008316 2.330010
## PTLG007_BL 1.0695567 2.463802
## PTLG008_BL 1.0553373 2.433801
## CD16+CD56-NKcells_MAPKAPK2_Unstim
## PTLG002_BL 1.931368
## PTLG003_BL 2.296781
## PTLG004_BL 2.340284
## PTLG005_BL 2.008033
## PTLG007_BL 2.159892
## PTLG008_BL 2.031384
## CD4+Tcells_mem_MAPKAPK2_Unstim CD4+Tcells_naive_MAPKAPK2_Unstim
## PTLG002_BL 2.164991 2.177987
## PTLG003_BL 2.417824 2.452165
## PTLG004_BL 2.433388 2.456412
## PTLG005_BL 2.268499 2.324646
## PTLG007_BL 2.338540 2.433700
## PTLG008_BL 2.259344 2.300202
## CD4+Tcells_MAPKAPK2_Unstim CD45RA+Tregs_MAPKAPK2_Unstim
## PTLG002_BL 2.168045 2.228993
## PTLG003_BL 2.429521 2.411254
## PTLG004_BL 2.442567 2.463470
## PTLG005_BL 2.304629 2.259092
## PTLG007_BL 2.372634 2.360412
## PTLG008_BL 2.270217 2.346650
## CD45RA-Tregs_MAPKAPK2_Unstim CD56+CD16-NKcells_MAPKAPK2_Unstim
## PTLG002_BL 2.019263 2.090901
## PTLG003_BL 2.285138 2.397106
## PTLG004_BL 2.351383 2.467930
## PTLG005_BL 2.177349 2.200985
## PTLG007_BL 2.224469 2.389535
## PTLG008_BL 2.219661 2.157265
## CD7+NKcells_MAPKAPK2_Unstim CD8+Tcells_mem_MAPKAPK2_Unstim
## PTLG002_BL 1.948561 1.927697
## PTLG003_BL 2.293079 2.258098
## PTLG004_BL 2.309057 2.300672
## PTLG005_BL 2.018246 2.023038
## PTLG007_BL 2.177767 2.118605
## PTLG008_BL 2.040020 2.045901
## CD8+Tcells_naive_MAPKAPK2_Unstim CD8+Tcells_MAPKAPK2_Unstim
## PTLG002_BL 2.101837 1.999748
## PTLG003_BL 2.388698 2.340109
## PTLG004_BL 2.468164 2.389146
## PTLG005_BL 2.259459 2.154734
## PTLG007_BL 2.211221 2.160966
## PTLG008_BL 2.225835 2.109784
## cMCs_MAPKAPK2_Unstim Gr_MAPKAPK2_Unstim intMCs_MAPKAPK2_Unstim
## PTLG002_BL 2.787907 1.465086 3.052941
## PTLG003_BL 3.277790 1.670120 3.357350
## PTLG004_BL 3.027573 1.307057 3.401704
## PTLG005_BL 2.980996 1.507802 3.167351
## PTLG007_BL 3.294925 1.577113 3.286156
## PTLG008_BL 2.999085 1.505600 2.956786
## M-MDSC_MAPKAPK2_Unstim mDCs_MAPKAPK2_Unstim
## PTLG002_BL 2.397340 2.779791
## PTLG003_BL 2.928151 3.193225
## PTLG004_BL 2.900128 3.119748
## PTLG005_BL 2.880435 2.971891
## PTLG007_BL 3.149156 3.203224
## PTLG008_BL 2.848060 2.924449
## ncMCs_MAPKAPK2_Unstim pDCs_MAPKAPK2_Unstim
## PTLG002_BL 2.800869 2.489211
## PTLG003_BL 3.079928 2.928867
## PTLG004_BL 2.844681 2.799909
## PTLG005_BL 2.978613 2.614913
## PTLG007_BL 2.681825 2.946109
## PTLG008_BL 2.692226 2.703571
## Tbet+CD4+Tcells_mem_MAPKAPK2_Unstim
## PTLG002_BL 2.192613
## PTLG003_BL 2.447870
## PTLG004_BL 2.437286
## PTLG005_BL 2.390372
## PTLG007_BL 2.306304
## PTLG008_BL 2.297046
## Tbet+CD4+Tcells_naive_MAPKAPK2_Unstim
## PTLG002_BL 2.412884
## PTLG003_BL 2.601548
## PTLG004_BL 2.934042
## PTLG005_BL 2.691207
## PTLG007_BL 2.734232
## PTLG008_BL 2.767591
## Tbet+CD8+Tcells_mem_MAPKAPK2_Unstim
## PTLG002_BL 1.909634
## PTLG003_BL 2.262726
## PTLG004_BL 2.282981
## PTLG005_BL 2.070756
## PTLG007_BL 2.039986
## PTLG008_BL 2.018832
## Tbet+CD8+Tcells_naive_MAPKAPK2_Unstim
## PTLG002_BL 1.910503
## PTLG003_BL 2.240830
## PTLG004_BL 2.401180
## PTLG005_BL 2.158052
## PTLG007_BL 2.043273
## PTLG008_BL 2.015452
## TCRgd+Tcells_MAPKAPK2_Unstim Tregs_MAPKAPK2_Unstim
## PTLG002_BL 1.984294 2.033097
## PTLG003_BL 2.255083 2.303150
## PTLG004_BL 2.292578 2.356123
## PTLG005_BL 2.050059 2.211516
## PTLG007_BL 2.219666 2.247183
## PTLG008_BL 2.044427 2.228012
## Bcells_NFkB_Unstim CD16+CD56-NKcells_NFkB_Unstim
## PTLG002_BL 1.4458497 1.4910991
## PTLG003_BL 0.9206900 1.1232214
## PTLG004_BL 0.9371759 1.2436204
## PTLG005_BL 0.8770654 1.0539872
## PTLG007_BL 0.7366889 0.8596213
## PTLG008_BL 1.1750699 1.0783717
## CD4+Tcells_mem_NFkB_Unstim CD4+Tcells_naive_NFkB_Unstim
## PTLG002_BL 1.632975 1.607542
## PTLG003_BL 1.324165 1.261195
## PTLG004_BL 1.380164 1.268477
## PTLG005_BL 1.279351 1.206040
## PTLG007_BL 1.220138 1.046157
## PTLG008_BL 1.446791 1.307544
## CD4+Tcells_NFkB_Unstim CD45RA+Tregs_NFkB_Unstim
## PTLG002_BL 1.623583 1.617671
## PTLG003_BL 1.302311 1.178572
## PTLG004_BL 1.335830 1.230590
## PTLG005_BL 1.231706 1.163409
## PTLG007_BL 1.155630 1.046948
## PTLG008_BL 1.406186 1.381399
## CD45RA-Tregs_NFkB_Unstim CD56+CD16-NKcells_NFkB_Unstim
## PTLG002_BL 1.638626 1.5937663
## PTLG003_BL 1.308981 1.0137219
## PTLG004_BL 1.403047 1.2101123
## PTLG005_BL 1.289483 1.0405192
## PTLG007_BL 1.197792 0.9040109
## PTLG008_BL 1.478304 1.0793180
## CD7+NKcells_NFkB_Unstim CD8+Tcells_mem_NFkB_Unstim
## PTLG002_BL 1.4926102 1.728891
## PTLG003_BL 1.1107854 1.326994
## PTLG004_BL 1.1684240 1.457505
## PTLG005_BL 1.0477033 1.435162
## PTLG007_BL 0.8588911 1.092186
## PTLG008_BL 1.0745504 1.461774
## CD8+Tcells_naive_NFkB_Unstim CD8+Tcells_NFkB_Unstim
## PTLG002_BL 1.642127 1.691105
## PTLG003_BL 1.227144 1.261757
## PTLG004_BL 1.337660 1.393795
## PTLG005_BL 1.270122 1.342220
## PTLG007_BL 1.023970 1.058992
## PTLG008_BL 1.336478 1.416458
## cMCs_NFkB_Unstim Gr_NFkB_Unstim intMCs_NFkB_Unstim
## PTLG002_BL 1.729852 1.2274679 1.757834
## PTLG003_BL 1.590812 1.1576161 1.596200
## PTLG004_BL 1.316812 1.2362890 1.665765
## PTLG005_BL 1.165541 0.9697881 1.248084
## PTLG007_BL 1.522954 1.2164262 1.653461
## PTLG008_BL 1.720078 1.2251825 1.594150
## M-MDSC_NFkB_Unstim mDCs_NFkB_Unstim ncMCs_NFkB_Unstim
## PTLG002_BL 1.602751 1.515290 1.561404
## PTLG003_BL 1.504733 1.229887 1.258712
## PTLG004_BL 1.293251 1.148027 1.473683
## PTLG005_BL 1.136402 1.042600 1.111294
## PTLG007_BL 1.498294 1.110888 1.244453
## PTLG008_BL 1.661888 1.290704 1.345355
## pDCs_NFkB_Unstim Tbet+CD4+Tcells_mem_NFkB_Unstim
## PTLG002_BL 1.1537011 1.683029
## PTLG003_BL 0.9774160 1.384945
## PTLG004_BL 0.9195687 1.452596
## PTLG005_BL 0.8937160 1.336869
## PTLG007_BL 0.9995656 1.247298
## PTLG008_BL 1.2178527 1.523203
## Tbet+CD4+Tcells_naive_NFkB_Unstim
## PTLG002_BL 1.933948
## PTLG003_BL 1.426470
## PTLG004_BL 1.732628
## PTLG005_BL 1.514965
## PTLG007_BL 1.406111
## PTLG008_BL 1.738065
## Tbet+CD8+Tcells_mem_NFkB_Unstim
## PTLG002_BL 1.725984
## PTLG003_BL 1.350625
## PTLG004_BL 1.499026
## PTLG005_BL 1.533150
## PTLG007_BL 1.065169
## PTLG008_BL 1.503976
## Tbet+CD8+Tcells_naive_NFkB_Unstim TCRgd+Tcells_NFkB_Unstim
## PTLG002_BL 1.616800 2.050754
## PTLG003_BL 1.176163 1.571842
## PTLG004_BL 1.404741 1.738041
## PTLG005_BL 1.396201 1.551813
## PTLG007_BL 1.013323 1.258554
## PTLG008_BL 1.279902 1.548284
## Tregs_NFkB_Unstim Bcells_p38_Unstim
## PTLG002_BL 1.635611 0.5874340
## PTLG003_BL 1.299174 0.4289286
## PTLG004_BL 1.374045 0.3860600
## PTLG005_BL 1.263957 0.3368996
## PTLG007_BL 1.183838 0.4708600
## PTLG008_BL 1.476488 0.7696062
## CD16+CD56-NKcells_p38_Unstim CD4+Tcells_mem_p38_Unstim
## PTLG002_BL 0.3420677 0.3412101
## PTLG003_BL 0.2607995 0.2981333
## PTLG004_BL 0.3367351 0.2930308
## PTLG005_BL 0.2272648 0.2694310
## PTLG007_BL 0.2548116 0.3108401
## PTLG008_BL 0.2912784 0.3493613
## CD4+Tcells_naive_p38_Unstim CD4+Tcells_p38_Unstim
## PTLG002_BL 0.3219320 0.3350240
## PTLG003_BL 0.2676521 0.2876179
## PTLG004_BL 0.2665948 0.2826902
## PTLG005_BL 0.2417528 0.2518099
## PTLG007_BL 0.2799445 0.2996862
## PTLG008_BL 0.3187144 0.3414311
## CD45RA+Tregs_p38_Unstim CD45RA-Tregs_p38_Unstim
## PTLG002_BL 0.3580121 0.3758892
## PTLG003_BL 0.2791081 0.2774422
## PTLG004_BL 0.2296999 0.2820640
## PTLG005_BL 0.2439046 0.2635847
## PTLG007_BL 0.2900387 0.3063874
## PTLG008_BL 0.3715767 0.3743650
## CD56+CD16-NKcells_p38_Unstim CD7+NKcells_p38_Unstim
## PTLG002_BL 0.2888114 0.3337875
## PTLG003_BL 0.1878317 0.2556059
## PTLG004_BL 0.2428102 0.2646968
## PTLG005_BL 0.1803399 0.2248029
## PTLG007_BL 0.2049328 0.2488000
## PTLG008_BL 0.2322562 0.2845840
## CD8+Tcells_mem_p38_Unstim CD8+Tcells_naive_p38_Unstim
## PTLG002_BL 0.2998695 0.3274772
## PTLG003_BL 0.2556867 0.2593472
## PTLG004_BL 0.2448911 0.2738017
## PTLG005_BL 0.2158268 0.2415711
## PTLG007_BL 0.2528654 0.2551368
## PTLG008_BL 0.2746403 0.3112425
## CD8+Tcells_p38_Unstim cMCs_p38_Unstim Gr_p38_Unstim
## PTLG002_BL 0.3114686 1.3106981 0.2618205
## PTLG003_BL 0.2575795 1.4299531 0.2273975
## PTLG004_BL 0.2598755 0.7275654 0.1644483
## PTLG005_BL 0.2304204 0.9875000 0.1974761
## PTLG007_BL 0.2539345 1.7151328 0.2236036
## PTLG008_BL 0.2877266 1.4405293 0.2471002
## intMCs_p38_Unstim M-MDSC_p38_Unstim mDCs_p38_Unstim
## PTLG002_BL 1.4907795 1.0533968 1.2775610
## PTLG003_BL 1.2345905 1.2431856 1.4169818
## PTLG004_BL 1.1298753 0.6375527 0.7039510
## PTLG005_BL 0.9954956 0.8957083 0.9661649
## PTLG007_BL 1.2173737 1.6965473 1.5738887
## PTLG008_BL 1.0458115 1.3478662 1.3992787
## ncMCs_p38_Unstim pDCs_p38_Unstim Tbet+CD4+Tcells_mem_p38_Unstim
## PTLG002_BL 1.3702681 0.5983727 0.3489453
## PTLG003_BL 1.0195736 0.5934122 0.3037197
## PTLG004_BL 0.8428859 0.4164223 0.2762782
## PTLG005_BL 0.8943996 0.5100921 0.2961469
## PTLG007_BL 0.7389302 0.5509278 0.2960594
## PTLG008_BL 0.8613081 0.5618226 0.3667232
## Tbet+CD4+Tcells_naive_p38_Unstim Tbet+CD8+Tcells_mem_p38_Unstim
## PTLG002_BL 0.5635131 0.3182769
## PTLG003_BL 0.3765790 0.2588440
## PTLG004_BL 0.6528826 0.2408653
## PTLG005_BL 0.3980845 0.2125897
## PTLG007_BL 0.5366995 0.2545642
## PTLG008_BL 0.6564478 0.2707079
## Tbet+CD8+Tcells_naive_p38_Unstim TCRgd+Tcells_p38_Unstim
## PTLG002_BL 0.3249345 0.3734880
## PTLG003_BL 0.2570437 0.2671310
## PTLG004_BL 0.2723772 0.2230888
## PTLG005_BL 0.2315289 0.2098211
## PTLG007_BL 0.2482516 0.3109623
## PTLG008_BL 0.3096221 0.2574379
## Tregs_p38_Unstim Bcells_S6_Unstim CD16+CD56-NKcells_S6_Unstim
## PTLG002_BL 0.3784539 1.930306 1.0734334
## PTLG003_BL 0.2793828 1.878084 1.0721098
## PTLG004_BL 0.2747268 1.670232 1.0398857
## PTLG005_BL 0.2625646 1.834203 0.8787435
## PTLG007_BL 0.3080039 1.849743 1.0491883
## PTLG008_BL 0.3749344 1.876035 0.9557624
## CD4+Tcells_mem_S6_Unstim CD4+Tcells_naive_S6_Unstim
## PTLG002_BL 0.4016325 0.6457943
## PTLG003_BL 0.3255893 0.6400155
## PTLG004_BL 0.2344455 0.7725610
## PTLG005_BL 0.3521391 0.6572289
## PTLG007_BL 0.3012091 0.7160773
## PTLG008_BL 0.3359148 0.5692703
## CD4+Tcells_S6_Unstim CD45RA+Tregs_S6_Unstim
## PTLG002_BL 0.4760231 0.6224378
## PTLG003_BL 0.4293711 0.5877025
## PTLG004_BL 0.4409139 0.5919307
## PTLG005_BL 0.5450173 0.5867731
## PTLG007_BL 0.4482957 0.5597560
## PTLG008_BL 0.3963204 0.5419513
## CD45RA-Tregs_S6_Unstim CD56+CD16-NKcells_S6_Unstim
## PTLG002_BL 0.3359727 0.6744689
## PTLG003_BL 0.2830967 0.7231868
## PTLG004_BL 0.2076796 0.8419811
## PTLG005_BL 0.2926156 0.6947684
## PTLG007_BL 0.2386271 0.7462732
## PTLG008_BL 0.3286172 0.5272477
## CD7+NKcells_S6_Unstim CD8+Tcells_mem_S6_Unstim
## PTLG002_BL 1.0042266 0.5065821
## PTLG003_BL 1.0492967 0.4086545
## PTLG004_BL 0.8721581 0.2980804
## PTLG005_BL 0.8692915 0.5571489
## PTLG007_BL 1.0182885 0.3931909
## PTLG008_BL 0.9178381 0.5024024
## CD8+Tcells_naive_S6_Unstim CD8+Tcells_S6_Unstim cMCs_S6_Unstim
## PTLG002_BL 0.9850361 0.7062456 1.4882139
## PTLG003_BL 1.0900121 0.8422466 1.6479710
## PTLG004_BL 1.2410788 0.7944779 0.5753761
## PTLG005_BL 0.9736546 0.7893189 1.1647444
## PTLG007_BL 1.1460575 0.7536819 1.4702866
## PTLG008_BL 0.9178029 0.6478817 1.4457350
## Gr_S6_Unstim intMCs_S6_Unstim M-MDSC_S6_Unstim mDCs_S6_Unstim
## PTLG002_BL 0.7150361 1.3681202 1.2402753 1.2937126
## PTLG003_BL 0.8055508 1.3505985 1.3747832 1.3956525
## PTLG004_BL 0.5250316 0.9135330 0.4351164 0.5455454
## PTLG005_BL 0.5253063 0.9859561 1.0483856 1.0132584
## PTLG007_BL 0.6223058 1.2265534 1.3184417 1.0041317
## PTLG008_BL 0.5132232 0.9306923 1.2505613 1.1954048
## ncMCs_S6_Unstim pDCs_S6_Unstim Tbet+CD4+Tcells_mem_S6_Unstim
## PTLG002_BL 1.1149569 0.9473491 0.4723082
## PTLG003_BL 1.0009342 0.9254935 0.3960724
## PTLG004_BL 0.7919038 0.8040769 0.2775185
## PTLG005_BL 0.8984885 0.8005398 0.4100194
## PTLG007_BL 1.0303611 0.9492261 0.3506848
## PTLG008_BL 0.7430516 0.8140353 0.3986797
## Tbet+CD4+Tcells_naive_S6_Unstim Tbet+CD8+Tcells_mem_S6_Unstim
## PTLG002_BL 1.0575421 0.5086470
## PTLG003_BL 0.7881706 0.4265873
## PTLG004_BL 1.0953875 0.3201406
## PTLG005_BL 0.8850472 0.5994524
## PTLG007_BL 0.8997395 0.3972660
## PTLG008_BL 0.9322777 0.5478698
## Tbet+CD8+Tcells_naive_S6_Unstim TCRgd+Tcells_S6_Unstim
## PTLG002_BL 0.8301758 0.7412374
## PTLG003_BL 0.9519362 0.5948369
## PTLG004_BL 0.6492401 0.3701913
## PTLG005_BL 0.7355286 0.5924967
## PTLG007_BL 0.9237288 1.0957695
## PTLG008_BL 0.7574023 0.5262540
## Tregs_S6_Unstim Bcells_STAT1_Unstim
## PTLG002_BL 0.3517799 0.2173282
## PTLG003_BL 0.3132209 0.1653385
## PTLG004_BL 0.2375856 0.1756185
## PTLG005_BL 0.3882727 0.1333492
## PTLG007_BL 0.2724968 0.1555878
## PTLG008_BL 0.3452982 0.2389696
## CD16+CD56-NKcells_STAT1_Unstim CD4+Tcells_mem_STAT1_Unstim
## PTLG002_BL 0.1601705 0.1682887
## PTLG003_BL 0.1751036 0.1719418
## PTLG004_BL 0.2112317 0.1953503
## PTLG005_BL 0.1441915 0.1509593
## PTLG007_BL 0.1543973 0.1680713
## PTLG008_BL 0.1859641 0.2053465
## CD4+Tcells_naive_STAT1_Unstim CD4+Tcells_STAT1_Unstim
## PTLG002_BL 0.1620959 0.1662434
## PTLG003_BL 0.1651676 0.1697243
## PTLG004_BL 0.1913301 0.1935840
## PTLG005_BL 0.1301516 0.1375446
## PTLG007_BL 0.1559919 0.1637041
## PTLG008_BL 0.2075118 0.2059915
## CD45RA+Tregs_STAT1_Unstim CD45RA-Tregs_STAT1_Unstim
## PTLG002_BL 0.2131215 0.1636117
## PTLG003_BL 0.1563510 0.1579927
## PTLG004_BL 0.1852947 0.1914989
## PTLG005_BL 0.1233058 0.1452268
## PTLG007_BL 0.1574041 0.1564620
## PTLG008_BL 0.2182978 0.2113028
## CD56+CD16-NKcells_STAT1_Unstim CD7+NKcells_STAT1_Unstim
## PTLG002_BL 0.1651819 0.1609661
## PTLG003_BL 0.1295451 0.1698291
## PTLG004_BL 0.1815409 0.1763395
## PTLG005_BL 0.1086348 0.1410629
## PTLG007_BL 0.1423653 0.1515970
## PTLG008_BL 0.1691002 0.1829980
## CD8+Tcells_mem_STAT1_Unstim CD8+Tcells_naive_STAT1_Unstim
## PTLG002_BL 0.1488153 0.1607185
## PTLG003_BL 0.1540996 0.1624510
## PTLG004_BL 0.1720980 0.1966202
## PTLG005_BL 0.1225920 0.1342914
## PTLG007_BL 0.1453974 0.1430933
## PTLG008_BL 0.1611283 0.1891478
## CD8+Tcells_STAT1_Unstim cMCs_STAT1_Unstim Gr_STAT1_Unstim
## PTLG002_BL 0.1538079 0.5444915 0.2674106
## PTLG003_BL 0.1592279 0.6028097 0.2547346
## PTLG004_BL 0.1848295 0.5789640 0.2517249
## PTLG005_BL 0.1288318 0.4001107 0.2129104
## PTLG007_BL 0.1440179 0.6298806 0.2157086
## PTLG008_BL 0.1709610 0.5880563 0.2097999
## intMCs_STAT1_Unstim M-MDSC_STAT1_Unstim mDCs_STAT1_Unstim
## PTLG002_BL 0.7310422 0.4652058 0.4800233
## PTLG003_BL 0.7194218 0.5057740 0.5243222
## PTLG004_BL 0.7216133 0.5173512 0.5769989
## PTLG005_BL 0.5026929 0.3732078 0.3582773
## PTLG007_BL 0.6619458 0.6162480 0.4673856
## PTLG008_BL 0.6092257 0.5492420 0.5020325
## ncMCs_STAT1_Unstim pDCs_STAT1_Unstim
## PTLG002_BL 0.6700006 0.2745749
## PTLG003_BL 0.6345784 0.2836829
## PTLG004_BL 0.6893175 0.2705679
## PTLG005_BL 0.4334836 0.2574702
## PTLG007_BL 0.4038871 0.2868132
## PTLG008_BL 0.5209884 0.3068360
## Tbet+CD4+Tcells_mem_STAT1_Unstim
## PTLG002_BL 0.1751050
## PTLG003_BL 0.1718114
## PTLG004_BL 0.1818860
## PTLG005_BL 0.1671244
## PTLG007_BL 0.1647998
## PTLG008_BL 0.2131390
## Tbet+CD4+Tcells_naive_STAT1_Unstim
## PTLG002_BL 0.3208015
## PTLG003_BL 0.1950628
## PTLG004_BL 0.5381641
## PTLG005_BL 0.2736873
## PTLG007_BL 0.3466748
## PTLG008_BL 0.4251483
## Tbet+CD8+Tcells_mem_STAT1_Unstim
## PTLG002_BL 0.1540192
## PTLG003_BL 0.1511497
## PTLG004_BL 0.1645606
## PTLG005_BL 0.1232316
## PTLG007_BL 0.1441921
## PTLG008_BL 0.1579541
## Tbet+CD8+Tcells_naive_STAT1_Unstim TCRgd+Tcells_STAT1_Unstim
## PTLG002_BL 0.1484545 0.1608881
## PTLG003_BL 0.1546765 0.1498558
## PTLG004_BL 0.1765572 0.1661662
## PTLG005_BL 0.1396455 0.1348518
## PTLG007_BL 0.1366142 0.1861696
## PTLG008_BL 0.1768606 0.1708635
## Tregs_STAT1_Unstim Bcells_STAT3_Unstim
## PTLG002_BL 0.1662114 0.2781483
## PTLG003_BL 0.1603167 0.1625053
## PTLG004_BL 0.1873261 0.1718254
## PTLG005_BL 0.1455273 0.2120853
## PTLG007_BL 0.1562396 0.1630811
## PTLG008_BL 0.2135246 0.2225361
## CD16+CD56-NKcells_STAT3_Unstim CD4+Tcells_mem_STAT3_Unstim
## PTLG002_BL 0.2218000 0.2845663
## PTLG003_BL 0.1571439 0.3237056
## PTLG004_BL 0.2041983 0.2849812
## PTLG005_BL 0.1995070 0.3620370
## PTLG007_BL 0.1603064 0.3329184
## PTLG008_BL 0.1545146 0.4297146
## CD4+Tcells_naive_STAT3_Unstim CD4+Tcells_STAT3_Unstim
## PTLG002_BL 0.3356009 0.3013098
## PTLG003_BL 0.4034801 0.3510125
## PTLG004_BL 0.3652782 0.3170946
## PTLG005_BL 0.3678771 0.3662373
## PTLG007_BL 0.4285801 0.3684858
## PTLG008_BL 0.6534357 0.4939236
## CD45RA+Tregs_STAT3_Unstim CD45RA-Tregs_STAT3_Unstim
## PTLG002_BL 0.3864844 0.2641090
## PTLG003_BL 0.3128324 0.2692223
## PTLG004_BL 0.3045837 0.2497949
## PTLG005_BL 0.3038926 0.3106597
## PTLG007_BL 0.3211479 0.3014530
## PTLG008_BL 0.5114759 0.3606454
## CD56+CD16-NKcells_STAT3_Unstim CD7+NKcells_STAT3_Unstim
## PTLG002_BL 0.2393239 0.2211650
## PTLG003_BL 0.1389597 0.1560172
## PTLG004_BL 0.1505888 0.1668143
## PTLG005_BL 0.2045774 0.1993931
## PTLG007_BL 0.1732497 0.1599824
## PTLG008_BL 0.1504352 0.1531552
## CD8+Tcells_mem_STAT3_Unstim CD8+Tcells_naive_STAT3_Unstim
## PTLG002_BL 0.2178882 0.2709459
## PTLG003_BL 0.1745433 0.2512281
## PTLG004_BL 0.1887592 0.2843483
## PTLG005_BL 0.2065138 0.2840917
## PTLG007_BL 0.1838739 0.2202050
## PTLG008_BL 0.1843703 0.3486748
## CD8+Tcells_STAT3_Unstim cMCs_STAT3_Unstim Gr_STAT3_Unstim
## PTLG002_BL 0.2398396 0.5552704 0.5746168
## PTLG003_BL 0.2233878 0.5329927 0.5871720
## PTLG004_BL 0.2388598 0.7365765 0.7397921
## PTLG005_BL 0.2497757 0.6053640 0.6618063
## PTLG007_BL 0.2005771 0.6242293 0.7589489
## PTLG008_BL 0.2424071 0.5838936 0.7142144
## intMCs_STAT3_Unstim M-MDSC_STAT3_Unstim mDCs_STAT3_Unstim
## PTLG002_BL 0.5952397 0.5391052 0.5493400
## PTLG003_BL 0.5040039 0.5216607 0.5967189
## PTLG004_BL 0.8677943 0.8552758 0.5897723
## PTLG005_BL 0.5062227 0.6450598 0.5820798
## PTLG007_BL 0.5238370 0.6732392 0.6832180
## PTLG008_BL 0.4805024 0.6178903 0.5726557
## ncMCs_STAT3_Unstim pDCs_STAT3_Unstim
## PTLG002_BL 0.4942574 0.3503243
## PTLG003_BL 0.3897859 0.3328578
## PTLG004_BL 0.6645261 0.2903678
## PTLG005_BL 0.4454081 0.3886589
## PTLG007_BL 0.2812737 0.3587549
## PTLG008_BL 0.3594660 0.3556967
## Tbet+CD4+Tcells_mem_STAT3_Unstim
## PTLG002_BL 0.2493262
## PTLG003_BL 0.2266845
## PTLG004_BL 0.2142891
## PTLG005_BL 0.3131146
## PTLG007_BL 0.2320790
## PTLG008_BL 0.3097553
## Tbet+CD4+Tcells_naive_STAT3_Unstim
## PTLG002_BL 0.4818524
## PTLG003_BL 0.2904628
## PTLG004_BL 0.5536225
## PTLG005_BL 0.5261899
## PTLG007_BL 0.4896744
## PTLG008_BL 0.6811571
## Tbet+CD8+Tcells_mem_STAT3_Unstim
## PTLG002_BL 0.2189375
## PTLG003_BL 0.1578626
## PTLG004_BL 0.1709310
## PTLG005_BL 0.2022413
## PTLG007_BL 0.1639236
## PTLG008_BL 0.1678895
## Tbet+CD8+Tcells_naive_STAT3_Unstim TCRgd+Tcells_STAT3_Unstim
## PTLG002_BL 0.2218408 0.2519930
## PTLG003_BL 0.1634312 0.1816717
## PTLG004_BL 0.2064093 0.1901294
## PTLG005_BL 0.2201852 0.2324579
## PTLG007_BL 0.1588787 0.1895293
## PTLG008_BL 0.1721998 0.1742372
## Tregs_STAT3_Unstim Bcells_STAT5_Unstim
## PTLG002_BL 0.2749372 0.5080754
## PTLG003_BL 0.2696643 0.2746148
## PTLG004_BL 0.2489255 0.2753367
## PTLG005_BL 0.3107475 0.3198885
## PTLG007_BL 0.3027992 0.2222449
## PTLG008_BL 0.3672610 0.3596088
## CD16+CD56-NKcells_STAT5_Unstim CD4+Tcells_mem_STAT5_Unstim
## PTLG002_BL 0.4370299 0.5188143
## PTLG003_BL 0.3536102 0.4791554
## PTLG004_BL 0.4106613 0.4925632
## PTLG005_BL 0.3824558 0.4873415
## PTLG007_BL 0.3033436 0.4470768
## PTLG008_BL 0.3591477 0.5123885
## CD4+Tcells_naive_STAT5_Unstim CD4+Tcells_STAT5_Unstim
## PTLG002_BL 0.5319969 0.5231944
## PTLG003_BL 0.4937010 0.4840921
## PTLG004_BL 0.5093203 0.4989418
## PTLG005_BL 0.4657778 0.4737736
## PTLG007_BL 0.4565514 0.4503689
## PTLG008_BL 0.5411095 0.5213035
## CD45RA+Tregs_STAT5_Unstim CD45RA-Tregs_STAT5_Unstim
## PTLG002_BL 0.6418038 0.5244315
## PTLG003_BL 0.4078199 0.3828482
## PTLG004_BL 0.4698334 0.4342122
## PTLG005_BL 0.4109841 0.4190715
## PTLG007_BL 0.3458056 0.3345147
## PTLG008_BL 0.5153179 0.4317007
## CD56+CD16-NKcells_STAT5_Unstim CD7+NKcells_STAT5_Unstim
## PTLG002_BL 0.4594220 0.4393125
## PTLG003_BL 0.3274354 0.3529796
## PTLG004_BL 0.3978362 0.3660071
## PTLG005_BL 0.4254497 0.3882079
## PTLG007_BL 0.3374606 0.2994207
## PTLG008_BL 0.3564407 0.3531437
## CD8+Tcells_mem_STAT5_Unstim CD8+Tcells_naive_STAT5_Unstim
## PTLG002_BL 0.4664585 0.5471628
## PTLG003_BL 0.3849776 0.4295466
## PTLG004_BL 0.3966512 0.5437557
## PTLG005_BL 0.4105237 0.5067977
## PTLG007_BL 0.3487510 0.3753280
## PTLG008_BL 0.4020581 0.4785952
## CD8+Tcells_STAT5_Unstim cMCs_STAT5_Unstim Gr_STAT5_Unstim
## PTLG002_BL 0.5003172 1.0997438 0.7654855
## PTLG003_BL 0.4134202 1.0024210 0.5889620
## PTLG004_BL 0.4741971 0.8906038 0.4764761
## PTLG005_BL 0.4639764 0.9922790 0.6257502
## PTLG007_BL 0.3609189 0.8873429 0.5034246
## PTLG008_BL 0.4290462 0.8757932 0.4601436
## intMCs_STAT5_Unstim M-MDSC_STAT5_Unstim mDCs_STAT5_Unstim
## PTLG002_BL 1.3269441 0.9989541 0.9536371
## PTLG003_BL 1.1261494 0.9448678 0.8219467
## PTLG004_BL 1.2176661 0.8904046 0.8004679
## PTLG005_BL 1.0980149 0.9935417 0.7914198
## PTLG007_BL 0.9748642 0.9058031 0.6493813
## PTLG008_BL 0.9085742 0.8440518 0.7590346
## ncMCs_STAT5_Unstim pDCs_STAT5_Unstim
## PTLG002_BL 1.0826295 0.8086104
## PTLG003_BL 0.9074171 0.6042555
## PTLG004_BL 1.0677888 0.5636154
## PTLG005_BL 0.8695965 0.6801389
## PTLG007_BL 0.5646013 0.5480772
## PTLG008_BL 0.7263003 0.5794442
## Tbet+CD4+Tcells_mem_STAT5_Unstim
## PTLG002_BL 0.5042688
## PTLG003_BL 0.4494896
## PTLG004_BL 0.4645632
## PTLG005_BL 0.5063484
## PTLG007_BL 0.3938714
## PTLG008_BL 0.4756519
## Tbet+CD4+Tcells_naive_STAT5_Unstim
## PTLG002_BL 0.7574242
## PTLG003_BL 0.4938482
## PTLG004_BL 1.0044966
## PTLG005_BL 0.7539782
## PTLG007_BL 0.6493930
## PTLG008_BL 0.8755706
## Tbet+CD8+Tcells_mem_STAT5_Unstim
## PTLG002_BL 0.4620451
## PTLG003_BL 0.3694388
## PTLG004_BL 0.3785570
## PTLG005_BL 0.4029049
## PTLG007_BL 0.3210094
## PTLG008_BL 0.3816272
## Tbet+CD8+Tcells_naive_STAT5_Unstim TCRgd+Tcells_STAT5_Unstim
## PTLG002_BL 0.4546654 0.4438595
## PTLG003_BL 0.3524330 0.3120759
## PTLG004_BL 0.4235297 0.3323679
## PTLG005_BL 0.4344997 0.3718802
## PTLG007_BL 0.3003717 0.2974487
## PTLG008_BL 0.3565438 0.3283151
## Tregs_STAT5_Unstim
## PTLG002_BL 0.5294306
## PTLG003_BL 0.3885832
## PTLG004_BL 0.4479044
## PTLG005_BL 0.4218850
## PTLG007_BL 0.3328335
## PTLG008_BL 0.4391577dis_im <- scale(df_im[18:33,], center = TRUE)
##use pvclust to get a confidence values
pv_im <- pvclust(t(dis_im), nboot=1000)## Bootstrap (r = 0.5)... Done.
## Bootstrap (r = 0.6)... Done.
## Bootstrap (r = 0.7)... Done.
## Bootstrap (r = 0.8)... Done.
## Bootstrap (r = 0.9)... Done.
## Bootstrap (r = 1.0)... Done.
## Bootstrap (r = 1.1)... Done.
## Bootstrap (r = 1.2)... Done.
## Bootstrap (r = 1.3)... Done.
## Bootstrap (r = 1.4)... Done.plot(pv_im, cex=0.8, cex.pv=0.7)
X <- df2
Y <- df_im[18:33,]
shrink <- rcc(X, Y, ncomp = 3, method = "shrinkage")
plot(shrink, scree.type = "barplot")
grid1 <- seq(0.05, 0.2, length = 5)
grid2 <- seq(0.05, 0.2, length = 5)
cv <- tune.rcc(X, Y, grid1 = grid1, grid2 = grid2, validation = "loo")
test.rcc <- rcc(X,Y, ncomp = 6, lambda1 = cv$opt.lambda1,
lambda2 = cv$opt.lambda2)
plotVar(test.rcc, comp = 3:4, cutoff = 0.6, var.names = c(TRUE, TRUE),
cex = c(2, 2), title = 'Nutrimouse, rCCA comp 3 - 4')
plotVar(test.rcc, comp = 4:5, cutoff = 0.5, var.names = c(TRUE, TRUE),
cex = c(2, 2), title = 'Nutrimouse, rCCA comp 4 - 5')